The psychometric properties of the Parkinson's Impact Scale (PIMS) as a measure of quality of life in Parkinson's disease
| Autor: | Edwin Mak, S. Calne, Michael Schulzer |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Parkinson's disease Psychometrics Context (language use) law.invention Antiparkinson Agents Nitrophenols Benzophenones Physical medicine and rehabilitation Quality of life Randomized controlled trial law hemic and lymphatic diseases medicine Humans Reliability (statistics) Cross-Over Studies Tolcapone Reproducibility of Results Construct validity Parkinson Disease medicine.disease Clinical trial Neurology Area Under Curve Quality of Life Physical therapy Neurology (clinical) Geriatrics and Gerontology Psychology medicine.drug |
| Zdroj: | Parkinsonism & Related Disorders. 9:291-294 |
| ISSN: | 1353-8020 |
| DOI: | 10.1016/s1353-8020(03)00019-1 |
| Popis: | We have previously designed and validated a 10-item bilingual questionnaire, the Parkinson's Impact Scale (PIMS), as a disease-specific instrument to measure the impact of Parkinson's disease (PD) on the quality of life of patients with PD. In this paper we extend the psychometric assessment of PIMS to a new set of patients, in the context of a cross-over trial by Hoffman-La Roche Ltd, comparing two doses of tolcapone in 116 PD patients who had developed wearing off effect on levodopa. Using data from this trial, we evaluate PIMS' test-retest reliability, construct validity, sensitivity and responsiveness to change. Validation is carried out by correlating the PIMS scores with corresponding UPDRS subscales and with the Schwab and England scale. We show that PIMS has excellent psychometric properties, and can therefore be used not only in clinical trials but also to identify quickly potential problems in major subjective areas of PD patients' lives, in order to refer them effectively to appropriate providers of assistance. |
| Databáze: | OpenAIRE |
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