Executive dysfunctions differentially predict amotivation in first-episode schizophrenia-spectrum disorder: a prospective 1-year follow-up study
| Autor: | Christy L.M. Hui, Jasmine Tsz Ting Liu, Wing Chung Chang, Sherry Kit Wa Chan, Yi Nam Suen, Edwin Ho Ming Lee, Eric Y.H. Chen |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Adolescent Anhedonia Apathy 03 medical and health sciences Executive Function Young Adult 0302 clinical medicine medicine Humans Pharmacology (medical) Spectrum disorder Prospective Studies Biological Psychiatry Psychiatric Status Rating Scales Motivation Working memory business.industry Amotivation Cognitive flexibility Flexibility (personality) Cognition General Medicine Middle Aged medicine.disease 030227 psychiatry Psychiatry and Mental health Schizophrenia Female Schizophrenic Psychology business 030217 neurology & neurosurgery Clinical psychology Executive dysfunction Follow-Up Studies |
| Zdroj: | European archives of psychiatry and clinical neuroscience. 269(8) |
| ISSN: | 1433-8491 |
| Popis: | Amotivation is a major determinant of functional outcome in schizophrenia but it is understudied in the early course of illness. There is a paucity of longitudinal research investigating predictors of amotivation. In this study, we aimed to examine baseline cognitive and clinical predictors of amotivation at 6 and 12 months of follow-up in patients aged 18–55 years presenting with first-episode DSM-IV schizophrenia-spectrum disorder (FES). Of 145 patients recruited at intake, 116 and 113 completed assessments at 6- and 12-month follow-up, respectively. Amotivation was measured by avolition-apathy and anhedonia-asociality subscale scores of the Scale of the Assessment of Negative Symptoms. Cognitive assessment was administered at baseline. As executive dysfunction has been more consistently found to be associated with negative symptoms and amotivation in prior literature, we adopted fractionated approach to subdivide executive function into distinct components encompassing switching and flexibility, response initiation, response inhibition, planning and strategy allocation, sustained attention and working memory. Our results showed that baseline amotivation (p = 0.01) and switching and flexibility (p = 0.01) were found to independently predict amotivation at 6 months follow-up. Baseline amotivation (p |
| Databáze: | OpenAIRE |
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