In situ self-assembling Au-DNA complexes for targeted cancer bioimaging and inhibition
| Autor: | Yossi Weizmann, Maonan Wang, Xuemei Wang, Huan Feng, Hui Jiang, Alberto Pasquarelli, Yun Chen, Weiwei Liu, Tianyu Du, Weijuan Cai |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
In situ
medicine.medical_treatment Phosphatase Metal Nanoparticles Theranostic Nanomedicine Targeted therapy chemistry.chemical_compound Mice In vivo Cell Line Tumor Neoplasms Tumor Microenvironment Tensin Medicine Animals Humans Multidisciplinary business.industry PTEN Phosphohydrolase Cancer DNA Biological Sciences medicine.disease In vitro Disease Models Animal chemistry A549 Cells Cancer research Gold business HeLa Cells |
| Zdroj: | Proc Natl Acad Sci U S A |
| Popis: | Cancer remains one of the most challenging diseases to treat. For accurate cancer diagnosis and targeted therapy, it is important to assess the localization of the affected area of cancers. The general approaches for cancer diagnostics include pathological assessments and imaging. However, these methods only generally assess the tumor area. In this study, by taking advantage of the unique microenvironment of cancers, we effectively utilize in situ self-assembled biosynthetic fluorescent gold nanocluster-DNA (GNC-DNA) complexes to facilitate safe and targeted cancer theranostics. In in vitro and in vivo tumor models, our self-assembling biosynthetic approach allowed for precise bioimaging and inhibited cancer growth after one injection of DNA and gold precursors. These results demonstrate that in situ bioresponsive self-assembling GNC-PTEN (phosphatase and tensin homolog) complexes could be an effective noninvasive technique for accurate cancer bioimaging and treatment, thus providing a safe and promising cancer theranostics platform for cancer therapy. |
| Databáze: | OpenAIRE |
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