Disrupted coupling of large-scale networks is associated with relapse behaviour in heroin-dependent men
| Autor: | Qiang Li, Jierong Liu, Wei Wang, Yarong Wang, Wei Li, Jiajie Chen, Jia Zhu, Xuejiao Yan, Yongbin Li, Zhe Li, Jianjun Ye |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Early remission Heroin Young Adult 03 medical and health sciences 0302 clinical medicine Recurrence Functional neuroimaging Internal medicine Neural Pathways medicine Humans Pharmacology (medical) Young adult Biological Psychiatry Default mode network Anterior cingulate cortex medicine.diagnostic_test Heroin Dependence business.industry Functional Neuroimaging Case-control study Magnetic resonance imaging Magnetic Resonance Imaging 030227 psychiatry Psychiatry and Mental health medicine.anatomical_structure Case-Control Studies business 030217 neurology & neurosurgery Research Paper medicine.drug |
| Zdroj: | Journal of Psychiatry & Neuroscience. 43:48-57 |
| ISSN: | 1180-4882 |
| DOI: | 10.1503/jpn.170011 |
| Popis: | BACKGROUND It is unknown whether impaired coupling among 3 core large-scale brain networks (salience [SN], default mode [DMN] and executive control networks [ECN]) is associated with relapse behaviour in treated heroin-dependent patients. METHODS We conducted a prospective resting-state functional MRI study comparing the functional connectivity strength among healthy controls and heroin-dependent men who had either relapsed or were in early remission. Men were considered to be either relapsed or in early remission based on urine drug screens during a 3-month follow-up period. We also examined how the coupling of large-scale networks correlated with relapse behaviour among heroin-dependent men. RESULTS We included 20 controls and 50 heroin-dependent men (26 relapsed and 24 early remission) in our analyses. The relapsed men showed greater connectivity than the early remission and control groups between the dorsal anterior cingulate cortex (key node of the SN) and the dorsomedial prefrontal cortex (included in the DMN). The relapsed men and controls showed lower connectivity than the early remission group between the left dorsolateral prefrontal cortex (key node of the left ECN) and the dorsomedial prefrontal cortex. The percentage of positive urine drug screens positively correlated with the coupling between the dorsal anterior cingulate cortex and dorsomedial prefrontal cortex, but negatively correlated with the coupling between the left dorsolateral prefrontal cortex and dorsomedial prefrontal cortex. LIMITATIONS We examined deficits in only 3 core networks leading to relapse behaviour. Other networks may also contribute to relapse. CONCLUSION Greater coupling between the SN and DMN and lower coupling between the left ECN and DMN is associated with relapse behaviour. These findings may shed light on the development of new treatments for heroin addiction. |
| Databáze: | OpenAIRE |
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