Clinical status, psychosocial impairments, medical treatment and health care costs for patients with inflammatory bowel disease (IBD) in Germany: An online IBD registry
| Autor: | Anne Prenzler, D. Hüppe, M. Düffelmeyer, M. Hoffstadt, S. Conrad, Bernd Bokemeyer, T. Klugmann, Thomas Mittendorf, Heiner Raspe, Carsten Schmidt, J. Hardt, J. Weismüller, P. Hartmann |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Pancolitis Time Factors Sexual Behavior Azathioprine Severity of Illness Index Inflammatory bowel disease Drug Costs Sex Factors Crohn Disease Adrenal Cortex Hormones Germany Surveys and Questionnaires Internal medicine Severity of illness medicine Humans Obesity Registries Internet Crohn's disease Depression business.industry Anti-Inflammatory Agents Non-Steroidal Smoking Age Factors Gastroenterology Antibodies Monoclonal General Medicine Middle Aged medicine.disease Ulcerative colitis Crohn's Disease Activity Index Infliximab C-Reactive Protein Cross-Sectional Studies Physical therapy Colitis Ulcerative Female medicine.symptom business Immunosuppressive Agents medicine.drug |
| Zdroj: | Journal of Crohn's and Colitis. 7:355-368 |
| ISSN: | 1873-9946 |
| Popis: | Background The aim of this cross-sectional study was to establish an online inflammatory bowel disease (IBD) registry for a first picture of the situation of IBD outpatients' treatment in Germany. Methods Between March 2006 and July 2007 IBD outpatients from 24 gastroenterological specialist practices and two hospitals in Germany were enrolled in an Internet-based registry to evaluate the outpatients' clinical status, psychological impairments, provided health care, as well as medical treatment and medication costs. Results 1032 IBD patients (ulcerative colitis/UC: 519; Crohn's disease/CD: 511; indeterminate colitis: 2) were enrolled in the study (age: 43 ± 14 years/M ± SD). Disease duration of all patients averaged 10 ± 8.5 years. In 519 UC-patients (49% male; 33% pancolitis), 66% were in remission as were 55% of CD patients (37 % male; 41 % active smokers). Associated with higher rates of disease activity (CDAI ≥ 150; CAI > 4) were corticosteroids (CD, UC), topical medication (UC), relevant reported depressive symptoms (15%; 6-31%) and impairments in sexuality (21%; 9-42%). Relevant medication groups prescribed were oral aminosalicylates (UC: 70%; CD: 47%); immunosuppressive therapy - mostly azathioprine/6 MP (CD: 47%; UC: 26%), and Infliximab (CD: 8%; UC: 3%). Strongly associated with their clinical disease activity in UC as well as CD patients, 15% (6–31%) reported relevant depressive symptoms and 21% (9–42%) relevant impairments in sexuality. Conclusions The registry constitutes a large complemental database for the patient population in Germany. About one third of the IBD patients were not in clinical remission (CDAI ≥ 150/CAI > 4) (CD: 45%; UC: 27%), although high rates of immunosuppressive drugs (CD: 47%; UC 26%) were administered. This study shows a large burden of active disease associated with an unexpectedly high (co)morbidity and high psychosocial impairments, indicating a reduced health state in IBD patients. |
| Databáze: | OpenAIRE |
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