| Autor: |
Evangelos Oikonomou, Nektarios Souvaliotis, Stamatios Lampsas, Gerasimos Siasos, Garyphallia Poulakou, Panagiotis Theofilis, Theodore G. Papaioannou, Anna-Bettina Haidich, Georgia Tsaousi, Vasileios Ntousopoulos, Vissaria Sakka, Georgios Charalambous, Vasiliki Rapti, Sylvia Raftopoulou, Konstantinos Syrigos, Costas Tsioufis, Dimitris Tousoulis, Manolis Vavuranakis |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Vascular pharmacology. 144 |
| ISSN: |
1879-3649 |
| Popis: |
Coronavirus disease-19 (COVID-19) is implicated by active endotheliitis, and cardiovascular morbidity. The long-COVID-19 syndrome implications in atherosclerosis have not been elucidated yet. We assessed the immediate, intermediate, and long-term effects of COVID-19 on endothelial function.In this prospective cohort study, patients hospitalized for COVID-19 at the medical ward or Intensive Care Unit (ICU) were enrolled and followed up to 6 months post-hospital discharge. Medical history and laboratory examinations were performed while the endothelial function was assessed by brachial artery flow-mediated dilation (FMD). Comparison with propensity score-matched cohort (control group) was performed at the acute (upon hospital admission) and follow-up (1 and 6 months) stages.Seventy-three patients diagnosed with COVID-19 (37% admitted in ICU) were recruited. FMD was significantly (p 0.001) impaired in the COVID-19 group (1.65 ± 2.31%) compared to the control (6.51 ± 2.91%). ICU-treated subjects presented significantly impaired (p = 0.001) FMD (0.48 ± 1.01%) compared to those treated in the medical ward (2.33 ± 2.57%). During hospitalization, FMD was inversely associated with Interleukin-6 and Troponin I (p 0.05 for all). Although, a significant improvement in FMD was noted during the follow-up (acute: 1.75 ± 2.19% vs. 1 month: 4.23 ± 2.02%, vs. 6 months: 5.24 ± 1.62%; p = 0.001), FMD remained impaired compared to control (6.48 ± 3.08%) at 1 month (p 0.001) and 6 months (p = 0.01) post-hospital discharge.COVID-19 patients develop a notable endothelial dysfunction, which is progressively improved over a 6-month follow-up but remains impaired compared to healthy controls subjects. Whether chronic dysregulation of endothelial function following COVID-19 could be accompanied by a residual risk for cardiovascular and thrombotic events merits further research. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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