TRH-DEGRADING ENZYME ACTIVITY IN PERIPHERAL AND PITUITARY-PORTAL PLASMA OF THE RAT
| Autor: | D. Schock, M. Ching, K. M. Knigge |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Endocrinology Diabetes and Metabolism Endogeny Endocrinology Internal medicine medicine Animals Enzyme inducer Thyrotropin-Releasing Hormone chemistry.chemical_classification biology Blood Proteins General Medicine Plasma Blood proteins Enzyme assay Enzymes Rats Peripheral Enzyme chemistry Pituitary Gland biology.protein Dialysis (biochemistry) hormones hormone substitutes and hormone antagonists |
| Zdroj: | Acta Endocrinologica. 83:449-453 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/acta.0.0830449 |
| Popis: | The enzymatic degradation of TRH was measured in peripheral and pituitary-portal plasma. Enzyme activity in peripheral plasma was 3.20 pg/min/μg plasma protein; in pituitary-portal plasma the rate of degradation was only 0.83 pg/min/μg protein. After dialysis, which removed virtually all endogenous TRH and LHRH, enzyme activity in peripheral and portal plasma was 2.24 and 0.60 pg/min/μg respectively. These data suggest that portal plasma contains large concentrations of unidentified substances which are competitive inhibitors or substrates for the enzyme or that portal plasma contains less TRH-degrading enzyme. |
| Databáze: | OpenAIRE |
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