Low-grade systemic inflammation: a partial mediator of the relationship between diabetes and lung function
| Autor: | Jean-Louis Edmé, Aline Meirhaeghe, Luc Dauchet, Natalie Chérot-Kornobis, Sébastien Hulo, Jonathan Giovannelli, Alina Ciuchete, Philippe Amouyel, Régis Matran, Philippe Trouiller |
|---|---|
| Přispěvatelé: | Service d'Epidémiologie et de Santé Publique [Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP), Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 (RID-AGE), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Faculté de Médecine Henri Warembourg - Université de Lille, Impact de l'environnement chimique sur la santé humaine - ULR 4483 (IMPECS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CHU Lille, Inserm, Université de Lille, IMPact de l’Environnement Chimique sur la Santé humaine (IMPECS) - EA 4483, IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483, Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE], Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement (RID-AGE) - U1167, Centre Hospitalier Régional Universitaire [Lille] [CHRU Lille] |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Lung Diseases Male medicine.medical_specialty Vital capacity Epidemiology [SDV]Life Sciences [q-bio] Vital Capacity 030209 endocrinology & metabolism Inflammation Disease Systemic inflammation Gastroenterology Diabetes complication 03 medical and health sciences FEV1/FVC ratio 0302 clinical medicine Diabetes mellitus Internal medicine Forced Expiratory Volume medicine Diabetes Mellitus Humans 030212 general & internal medicine Lung Diabetes Complication biology business.industry C-reactive protein Middle Aged medicine.disease Lung function Respiratory Function Tests C-Reactive Protein Cross-Sectional Studies biology.protein Mediation analysis Female medicine.symptom business Biomarkers |
| Zdroj: | Annals of Epidemiology Annals of Epidemiology, 2018, Annals of Epidemiology, 28 (1), pp.26-32. ⟨10.1016/j.annepidem.2017.11.004⟩ |
| ISSN: | 1873-2585 1047-2797 |
| Popis: | Purpose An association has been consistently found between diabetes mellitus and decreased lung function. We evaluated to what extent low-grade inflammation (as measured by the level of high-sensitivity C-reactive protein [hs-CRP]) could explain this relationship. Methods A sample of 1878 middle-aged adults from the cross-sectional Enquete Littoral Souffle Air Biologie Environnement survey without self-reported pulmonary and atherosclerosis disease was included. A mediation analysis was performed to assess and quantify the hs-CRP level as a mediator of the relationship between diabetes and lung function. Results Diabetes was associated with higher hs-CRP level (+22.9%, 95% confidence interval = [5.1, 43.6]). The hs-CRP (>4 vs. ≤1 mg/L) was associated with lower percentage predicted values for the forced expiratory volume in the first second (FEV1) (−4% [−6.1, −1.9]) and forced vital capacity (FVC) (−4.4% [−6.5, −2.3]). Diabetes was associated with FEV1 (−3.5% [−5.8, −1.3]) and FVC (−3.6% [−5.9, −1.3]). The proportion of the effect that is mediated by hs-CRP was 12% [2.4, 37] and 13% [3.7, 39.4] for FEV1 and FVC, respectively. Conclusions Our results suggest that low-grade systemic inflammation could only explain a small part of the relationship between diabetes and lung function. |
| Databáze: | OpenAIRE |
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