Evaluation of the serum levels of Mannose binding lectin‐2, tenascin‐C, and total antioxidant capacity in patients with coronary artery disease

Autor: Naser Aslanabadi, Behrouz Shademan, Fatemeh Khaki-Khatibi, Hamed Mehri, Alireza Nourazarian
Rok vydání: 2021
Předmět:
Male
Microbiology (medical)
medicine.medical_specialty
Hdl-Cholesterol
Mannose-binding lectin (2)
Thiobarbituric acid
Clinical Biochemistry
total antioxidant
Mannose‐binding lectin (2)
Coronary Artery Disease
Disease
Cardiovascular-Disease
Mannose-Binding Lectin
Gastroenterology
Antioxidants
Coronary artery disease
chemistry.chemical_compound
coronary artery disease (CAD)
Malondialdehyde
Internal medicine
Humans
Risk-Factors
Immunology and Allergy
Medicine
Family history
Research Articles
Aged
Mannan-binding lectin
Triglyceride
biology
business.industry
Biochemistry (medical)
Tenascin C
Public Health
Environmental and Occupational Health
Tenascin
Hematology
Middle Aged
medicine.disease
tenascin‐C
Medical Laboratory Technology
Cross-Sectional Studies
Blood pressure
chemistry
biology.protein
Female
tenascin-C
atherosclerosis
business
Research Article
Zdroj: Journal of Clinical Laboratory Analysis
ISSN: 1098-2825
0887-8013
Popis: Background Coronary artery disease (CAD) develops as a result of atherosclerosis. Atherosclerosis is a condition that leads to clogged arteries and can be caused by a variety of factors. Several studies have shown that various factors contribute to the development and progression of CAD. The aim of this study was to investigate the serum levels of MBL‐2, TNC and TAC in patients with CAD and the relationship between these biochemical parameters and the progression of CAD. Methods In this study, 60 serum samples were obtained from CAD patients as the case group and 20 healthy serum samples as the control group. Serum levels of MBL‐2 and TNC were measured by the ELISA method. Serum TAC level was determined by calorimetry (spectrophotometry). In addition, MDA serum level was measured by reaction with thiobarbituric acid (TBA). Results The mean age in the case and control groups was 58.4 ± 9.5 years and 85 ± 9.8 years, respectively. There was no significant difference in age, sex and family history in patients with CAD (p > 0.05), but there was a significant difference in blood pressure and smoking history (p > 0.05). Serum cholesterol, triglyceride, and LDL levels were significantly increased in the case group compared to the control group, while serum HDL‐C levels were significantly decreased in the case group. Serum levels of MBL‐2, TNC, and MDA were significantly increased in the case group compared to the control group. The serum level of TAC was significantly lower in the case group than in the control group. Conclusion This study suggests that it is possible to diagnose patients with coronary artery disease (CAD) in the early stages of their disease and take preventive measures by measuring these parameters in serum. However, more research is needed before these serum parameters can be considered diagnostic biomarkers or therapeutic targets.
Background: Coronary Artery Disease (CAD) develops as a result of atherosclerosis. Atherosclerosis is a condition that leads to clogged arteries and can be caused by a variety of factors. The aim of this study is to investigate the serum levels of MBL‐2, TNC and TAC in patients with CAD and the relationship between these biochemical parameters and the progression of CAD. Methods: In this study, 60 serum samples were obtained from CAD patients as the case group and 20 healthy serum samples as the control group. Serum levels of MBL‐2 and TNC were measured by the ELISA method. Serum TAC level was determined by calorimetry (spectrophotometry). In addition, MDA serum level was measured by reaction with thiobarbituric acid (TBA). Results: The mean age in the case and control groups was 58.4 ± 9.5 years and 85 ± 9.8 years, respectively. There was no significant difference in age, sex and family history in CAD patients (p > 0.05), but there was a significant difference in blood pressure and smoking history (p > 0.05). Serum levels of MBL‐2, TNC and MDA, were significantly increased in the case group compared to the control group. The serum level of TAC was significantly lower in the case group than in the control group. Conclusion: This study suggests that it is possible to diagnose patients with coronary artery disease (CAD) in the early stages of their disease and take preventive measures by measuring these parameters in serum. However, more research is needed before these serum parameters can be considered diagnostic biomarkers.
Databáze: OpenAIRE
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