Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia in conjunction with parotid basal cell adenoma: Cytologic, histologic, and molecular features
| Autor: | Abberly A. Lott Limbach, Anna-Karoline Israel, Mushal Noor, Donna Russell |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adenoma
Pathology medicine.medical_specialty Histology 030209 endocrinology & metabolism Thyroid Lobectomy Basal cell adenoma Pathology and Forensic Medicine Neoplasms Multiple Primary 03 medical and health sciences 0302 clinical medicine Mucoepidermoid carcinoma Eosinophilia Atypia medicine Humans Point Mutation Receptor trkC Thyroid Neoplasms Neurofibromin 1 medicine.diagnostic_test business.industry Thyroid General Medicine Middle Aged medicine.disease Parotid Neoplasms Fine-needle aspiration medicine.anatomical_structure Cytopathology 030220 oncology & carcinogenesis Carcinoma Mucoepidermoid Female Salivary Gland Mucoepidermoid Carcinoma business |
| Zdroj: | Diagnostic cytopathologyREFERENCES. 49(7) |
| ISSN: | 1097-0339 |
| Popis: | Sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE) is a rare malignancy in the thyroid: only 56 cases with histologic descriptions are reported in the literature and fewer reports describe the cytomorphology. Given the rarity of SMECE, data on the cytomorphologic and molecular features are limited. We report a case of a 53-year-old woman with a 5 cm left thyroid mass. Fine-needle aspiration (FNA) revealed atypia of undetermined significance and pathology of left thyroid lobectomy specimen showed SMECE. Additionally, a left pre-auricular lump was noted and FNA followed by left superficial parotidectomy showed basal cell adenoma. Next-generation sequencing showed point mutations in NTRK3 and NF1. Unlike salivary gland mucoepidermoid carcinoma, MAML2 translocations are not present in SMECE. Even though it is a rare entity, awareness of SMECE of the thyroid is important. In this case report we review the cytomorphologic, histologic, and molecular features. |
| Databáze: | OpenAIRE |
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