A neural heading estimate is compared with an internal goal to guide oriented navigation
| Autor: | Gaby Maimon, Atsuko Adachi, Peter Mussells Pires, Jonathan Green, Vikram Vijayan |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Heading (navigation) Computer science Article Task (project management) 03 medical and health sciences 0302 clinical medicine Orientation (geometry) Animals Computer vision Orientation Spatial Neurons business.industry Extramural General Neuroscience fungi Brain Bearing (navigation) 030104 developmental biology Trajectory Drosophila Female Artificial intelligence Cues business Neuroscience 030217 neurology & neurosurgery Spatial Navigation |
| Zdroj: | Nature neuroscience |
| ISSN: | 1546-1726 1097-6256 |
| DOI: | 10.1038/s41593-019-0444-x |
| Popis: | Goal-directed navigation is thought to rely on the activity of head-direction cells, but how this activity guides moment-to-moment actions remains poorly understood. Here we characterize how heading neurons in the Drosophila central complex guide moment-to-moment navigational behavior. We establish an innate, heading-neuron-dependent, tethered navigational behavior where walking flies maintain a straight trajectory along a specific angular bearing for hundreds of body lengths. While flies perform this task, we use chemogenetics to transiently rotate their neural heading estimate and observe that the flies slow down and turn in a direction that aims to return the heading estimate to the angle it occupied before stimulation. These results support a working model in which the fly brain quantitatively compares an internal estimate of current heading with an internal goal heading and uses the sign and magnitude of the difference to determine which way to turn, how hard to turn and how fast to walk forward. |
| Databáze: | OpenAIRE |
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