Clinical relevance of NKT cells and soluble MIC-A in Hodgkin lymphoma
| Autor: | Elba Reyes-Maldonado, Abraham Majluf-Cruz, Jorge Vela-Ojeda, Miriam García-Ruiz Esparza, Ana Cristina Olivas-Bejarano, Laura Montiel-Cervantes, Flor Perez-Retiguin, Jaime García-Chávez |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Cancer Research
business.industry Hematology Natural killer T cell Hodgkin Disease Lymphocyte Subsets 03 medical and health sciences 0302 clinical medicine Oncology Refractory immune system diseases T-Lymphocyte Subsets hemic and lymphatic diseases 030220 oncology & carcinogenesis Cancer research Hodgkin lymphoma Medicine Humans Natural Killer T-Cells Clinical significance Lymphocyte Count business After treatment 030215 immunology Lymphocyte subsets |
| Zdroj: | Leukemialymphoma. 62(4) |
| ISSN: | 1029-2403 |
| Popis: | Previous studies demonstrated that the majority of Hodgkin lymphoma (HL) patients achieve response after treatment, while 5% become refractory. Studies analyzing the role of lymphocyte subsets in peripheral blood are limited. This investigation sought to evaluate peripheral blood lymphocyte subsets and soluble MHC class I chain-related proteins A and B (sMIC-A/B) and their correlation with survival in patients with newly diagnosed HL. The study recruited 36 patients and 72 healthy donors. HL patients showed a decrease in CD4, B, monocytes, NK, and NKT cells; and an increase in γ-δ T cells and soluble MIC-A serum levels. Higher values of s-MIC |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|