Astrocytic and neuronal biochemical markers in the sera of subjects with diabetes mellitus
| Autor: | Susan E. Myers, Michael J. Haas, Anna Boyajyan, Astghik A. Guevorkyan, Arshag D. Mooradian, Ashot A. Mamikonyan, Meri R. Hovsepyan |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Blotting Western Enzyme-Linked Immunosorbent Assay S100 Calcium Binding Protein beta Subunit Blood–brain barrier Antigen Internal medicine Diabetes mellitus Diabetes Mellitus medicine Humans Nerve Growth Factors Child Aged Neurons biology business.industry General Neuroscience S100 Proteins Middle Aged medicine.disease Blot medicine.anatomical_structure Endocrinology nervous system Astrocytes Phosphopyruvate Hydratase biology.protein Neuroglia Female Antibody business Biomarkers Astrocyte |
| Zdroj: | Neuroscience Letters. 369:224-227 |
| ISSN: | 0304-3940 |
| Popis: | To determine if clinical diabetes is associated with disruption of the blood-brain barrier (BBB) and/or brain injury, enzyme-linked immunoassays and Western blots were used to measure serum levels of S100B, NSE and their auto-antibodies in type 1 and type 2 diabetic subjects. Serum S100B concentrations in type 2 diabetic subjects, but not in type 1 diabetic subjects, were significantly lower than those found in healthy controls. There were no significant differences in serum NSE levels of either type 1 or type 2 diabetics compared to healthy controls. However, there was a significant increase in antibodies to NSE in both type 1 and type 2 diabetic subjects compared to controls, whereas diabetics and controls had equally very low levels of anti S100B auto-antibodies. These studies suggest that diabetes in humans may be associated with alterations in the BBB integrity that allow the emergence of antibodies against neuronal antigens. |
| Databáze: | OpenAIRE |
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