TISIGNER.com: web services for improving recombinant protein production
| Autor: | Chun Shen Lim, Bikash K. Bhandari, Paul P. Gardner |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Signal peptide
Internet business.industry AcademicSubjects/SCI00010 Computational biology Biology Protein Sorting Signals computer.software_genre Recombinant Proteins Domain (software engineering) law.invention Open reading frame Solubility law Web Server Issue Genetics Recombinant DNA Coding region The Internet Web service business Peptide Chain Initiation Translational computer Software |
| Zdroj: | Nucleic Acids Research |
| ISSN: | 1362-4962 |
| Popis: | Experiments that are planned using accurate prediction algorithms will mitigate failures in recombinant protein production. We have developed TISIGNER (https://tisigner.com) with the aim of addressing technical challenges to recombinant protein production. We offer three web services, TIsigner (Translation Initiation coding region designer), SoDoPE (Soluble Domain for Protein Expression) and Razor, which are specialised in synonymous optimisation of recombinant protein expression, solubility and signal peptide analysis, respectively. Importantly, TIsigner, SoDoPE and Razor are linked, which allows users to switch between the tools when optimising genes of interest. Graphical Abstract Graphical AbstractOptimising recombinant protein production using TISIGNER.com |
| Databáze: | OpenAIRE |
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