Cerumenogram: a new frontier in cancer diagnosis in humans
| Autor: | Marina Ferraz Gontijo Soares, Lurian Caetano David, Nelson Roberto Antoniosi Filho, Naiara Zedes Pereira, Camilla Gabriela de Oliveira, Anselmo Elcana de Oliveira, João Marcos Gonçalves Barbosa, Engy Shokry, Melissa Ameloti Gomes Avelino |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Multivariate analysis lcsh:Medicine Medicinal chemistry New diagnosis Article Gas Chromatography-Mass Spectrometry 03 medical and health sciences 0302 clinical medicine Human disease Internal medicine Neoplasms medicine Humans Metabolomics Medical diagnosis lcsh:Science Cancer Volatile Organic Compounds Multidisciplinary Cerumen business.industry lcsh:R medicine.disease Magnetic Resonance Imaging 030104 developmental biology Neoplasms diagnosis Case-Control Studies lcsh:Q business Tomography X-Ray Computed 030217 neurology & neurosurgery Biomarkers |
| Zdroj: | Scientific Reports Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019) |
| ISSN: | 2045-2322 |
| Popis: | Cancer is the deadliest human disease and the development of new diagnosis methods is important to increase the chances of a cure. In this work it was developed a new method, named here for the first time as cerumenogram, using cerumen (earwax) as a new biomatrix for diagnosis. Earwax samples collected from cancer patients (cancer group) and cancer-free patients (control group) were analyzed by Headspace/Gas Chromatography-Mass Spectrometry (HS/GC-MS), following with multivariate analysis steps to process the raw data generated. In total, 158 volatile organic metabolites (VOMs) were identified in the cerumen samples. The 27 selected as potential VOMs biomarkers for cancer provided 100% discrimination between the cancer and control groups. This new test can thus be routinely employed for cancer diagnoses that is non-invasive, fast, cheap, and highly accurate. |
| Databáze: | OpenAIRE |
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