Altered Glutamate Receptor Ionotropic Delta Subunit 2 Expression in Stau2-Deficient Cerebellar Purkinje Cells in the Adult Brain
| Autor: | Michael A. Kiebler, Mehrnoosh Jafari, Tobias Straub, Helena F. Pernice, Martin Bilban, Rico Schieweck, Bastian Popper |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Cerebellum Aging cerebellum Purkinje cell Synaptogenesis Hippocampus GLUD2 Dendritic spine morphogenesis Nerve Tissue Proteins Motor Activity Catalysis Article Inorganic Chemistry lcsh:Chemistry medicine Animals RNA Messenger Physical and Theoretical Chemistry GluD2 Molecular Biology purkinje cells lcsh:QH301-705.5 Spectroscopy synaptogenesis Chemistry Organic Chemistry Glutamate receptor Brain RNA-Binding Proteins General Medicine Computer Science Applications Cell biology Mice Inbred C57BL staufen2 medicine.anatomical_structure Gene Expression Regulation Receptors Glutamate lcsh:Biology (General) lcsh:QD1-999 Female Gene Deletion Ionotropic effect |
| Zdroj: | International Journal of Molecular Sciences, Vol 20, Iss 7, p 1797 (2019) International Journal of Molecular Sciences Volume 20 Issue 7 |
| ISSN: | 1422-0067 |
| Popis: | Staufen2 (Stau2) is an RNA-binding protein that is involved in dendritic spine morphogenesis and function. Several studies have recently investigated the role of Stau2 in the regulation of its neuronal target mRNAs, with particular focus on the hippocampus. Here, we provide evidence for Stau2 expression and function in cerebellar Purkinje cells. We show that Stau2 downregulation (Stau2GT) led to an increase of glutamate receptor ionotropic delta subunit 2 (GluD2) in Purkinje cells when animals performed physical activity by voluntary wheel running compared with the age-matched wildtype (WT) mice (C57Bl/6J). Furthermore, Stau2GT mice showed lower performance in motor coordination assays but enhanced motor learning abilities than did WT mice, concomitantly with an increase in dendritic GluD2 expression. Together, our results suggest the novel role of Stau2 in Purkinje cell synaptogenesis in the mouse cerebellum. |
| Databáze: | OpenAIRE |
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