The importance of virion-incorporated cellular RNA-Binding Proteins in viral particle assembly and infectivity
| Autor: | Manuel Garcia-Moreno, Alfredo Castello, Kate Dicker, Aino I. Järvelin |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
viruses RNA-binding protein Review ZIKV Zika virus Virus Replication Genome 0302 clinical medicine RBP dsRNA Double-stranded RNA HBV Hepatitis B virus CLIP-seq Crosslinking and immunoprecipitation followed by sequencing Infectivity RNP Ribonucleoprotein RNA-Binding Proteins Protein-RNA interaction vRNP Viral ribonucleoprotein Virus IAV Influenza A virus Virus Diseases HIV-1 Human immunodeficiency virus 1 Proteome Host-Pathogen Interactions Viruses RSV Respiratory syncytial virus RNA Viral RBP RNA-binding protein ivRBP In virion RNA-binding protein dsDNA Double-stranded DNA Protein Binding Signal Transduction Virus infection Computational biology Biology vRNA Viral RNA HCV Hepatitis C virus pgRNA Pre-genomic RNA 03 medical and health sciences Viral Proteins GO Gene Ontology RIC RNA-interactome capture Humans RNA Messenger RBD RNA-binding domain Virus Assembly MeV Measles virus Virion RNA RNA virus Cell Biology biology.organism_classification RRM RNA-recognition motif 030104 developmental biology RVFV Rift Valley fever virus Viral replication Gene Expression Regulation Protein Biosynthesis PAMP Pathogen associated molecular pattern VSV Vesicular stomatitis virus SINV Sindbis virus DENV Dengue virus 4SU 4-thiouridine Ribosomes 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Seminars in Cell & Developmental Biology |
| ISSN: | 1096-3634 |
| Popis: | Highlights • Proteomic studies have uncovered more than a thousand cellular proteins that are present in the particles of RNA viruses. • Strikingly, nearly four hundred of these are RNA-binding proteins (RBPs). • Several virion-incorporated RBPs have been shown to regulate viral particle assembly and the initial steps of infection. • These host RBPs with regulatory roles in infection represent potential targets for antiviral therapy. RNA is a central molecule in RNA virus biology due to its dual function as messenger and genome. However, the small number of proteins encoded by viral genomes is insufficient to enable virus infection. Hence, viruses hijack cellular RNA-binding proteins (RBPs) to aid replication and spread. In this review we discuss the ‘knowns’ and ‘unknowns’ regarding the contribution of host RBPs to the formation of viral particles and the initial steps of infection in the newly infected cell. Through comparison of the virion proteomes of ten different human RNA viruses, we confirm that a pool of cellular RBPs are typically incorporated into viral particles. We describe here illustrative examples supporting the important functions of these RBPs in viral particle formation and infectivity and we propose that the role of host RBPs in these steps can be broader than previously anticipated. Understanding how cellular RBPs regulate virus infection can lead to the discovery of novel therapeutic targets against viruses. |
| Databáze: | OpenAIRE |
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