Polysaccharides Obtained from Cordyceps militaris Alleviate Hyperglycemia by Regulating Gut Microbiota in Mice Fed a High-Fat/Sucrose Diet
| Autor: | Yi-Yun Hsu, Bao-Hong Lee, Chia-Hsiu Chen, Pei-Ting Chuang, Ming-Kuei Shih, Wei Hsuan Hsu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Health (social science) Population polysaccharides Blood sugar TP1-1185 Plant Science Biology Gut flora Cordyceps militaris Health Professions (miscellaneous) Microbiology Article metabolic syndrome law.invention chemistry.chemical_compound Probiotic law Internal medicine medicine Akkermansia education education.field_of_study Cordycepin gut microbiota Chemical technology biology.organism_classification Endocrinology chemistry Akkermansia muciniphila Food Science |
| Zdroj: | Foods Volume 10 Issue 8 Foods, Vol 10, Iss 1870, p 1870 (2021) |
| ISSN: | 2304-8158 |
| DOI: | 10.3390/foods10081870 |
| Popis: | Polysaccharides isolated from fungus Cordyceps militaris display multi-biofunctions, such as immunostimulation, down-regulation of hyperlipidemia, and anti-cancer function. The occurrence of obesity and metabolic syndrome is related to the imbalance of gut microbiota. In this study, the effects of C. militaris and its fractions on modifying metabolic syndrome in mice were evaluated. Mice were fed a high-fat/high-sucrose diet (HFSD) for 14 weeks to induce body weight increase and hyperlipidemia symptoms in mice, and then the mice were simultaneously given a HFSD and C. militaris samples for a further 8 weeks. The results indicated that the fruit body, polysaccharides, and cordycepin obtained from C. militaris had different efficacies on regulating metabolic syndrome and gut microbiota in HFSD-treated mice. Polysaccharides derived from C. militaris decreased the levels of blood sugar and serum lipids in mice fed HFSD. In addition, C. militaris-polysaccharide treatment obviously improved intestinal dysbiosis through promoting the population of next generation probiotic Akkermansia muciniphila in the gut of mice fed HFSD. In conclusion, polysaccharides derived from C. militaris have the potential to act as dietary supplements and health food products for modifying the gut microbiota to improve the metabolic syndrome. |
| Databáze: | OpenAIRE |
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