The role of noncoding RNAs in Parkinson’s disease: biomarkers and associations with pathogenic pathways
Autor: | Ming-Che Kuo, Sam Chi-Hao Liu, Ruey-Meei Wu, Ya-Fang Hsu |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
RNA
Untranslated Endocrinology Diabetes and Metabolism Clinical Biochemistry PIWI-interacting RNA/piRNA Review Computational biology Disease Biology MicroRNA/miRNA Noncoding RNA Mice microRNA Gene expression Animals Humans Pharmacology (medical) Molecular Biology Long noncoding RNA/lncRNA Biochemistry (medical) Parkinson Disease RNA sequencing Biomarker Cell Biology General Medicine Non-coding RNA Microvesicles Disease Models Animal Parkinson’s disease Biomarker (medicine) Medicine Circular RNA/circRNA DNA microarray Biomarkers Biogenesis |
Zdroj: | Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-28 (2021) Journal of Biomedical Science |
ISSN: | 1423-0127 |
Popis: | The discovery of various noncoding RNAs (ncRNAs) and their biological implications is a growing area in cell biology. Increasing evidence has revealed canonical and noncanonical functions of long and small ncRNAs, including microRNAs, long ncRNAs (lncRNAs), circular RNAs, PIWI-interacting RNAs, and tRNA-derived fragments. These ncRNAs have the ability to regulate gene expression and modify metabolic pathways. Thus, they may have important roles as diagnostic biomarkers or therapeutic targets in various diseases, including neurodegenerative disorders, especially Parkinson’s disease. Recently, through diverse sequencing technologies and a wide variety of bioinformatic analytical tools, such as reverse transcriptase quantitative PCR, microarrays, next-generation sequencing and long-read sequencing, numerous ncRNAs have been shown to be associated with neurodegenerative disorders, including Parkinson’s disease. In this review article, we will first introduce the biogenesis of different ncRNAs, including microRNAs, PIWI-interacting RNAs, circular RNAs, long noncoding RNAs, and tRNA-derived fragments. The pros and cons of the detection platforms of ncRNAs and the reproducibility of bioinformatic analytical tools will be discussed in the second part. Finally, the recent discovery of numerous PD-associated ncRNAs and their association with the diagnosis and pathophysiology of PD are reviewed, and microRNAs and long ncRNAs that are transported by exosomes in biofluids are particularly emphasized. Supplementary Information The online version contains supplementary material available at 10.1186/s12929-021-00775-x. |
Databáze: | OpenAIRE |
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