Anthracene-Tethered Ruthenium(II) Arene Complexes as Tools To Visualize the Cellular Localization of Putative Organometallic Anticancer Compounds

Autor:	Olivier Zava, Albert Ruggi, Frédéric Schmitt, Christian G. Hartinger, Wee Han Ang, Julie Risse, Lucienne Juillerat-Jeanneret, Alexey A. Nazarov, Paul J. Dyson, Rosario Scopelitti, Michael Groessl
Rok vydání:	2012
Předmět:	Models Molecular Spectrometry Mass Electrospray Ionization Magnetic Resonance Spectroscopy Stereochemistry chemistry.chemical_element Antineoplastic Agents Decane Plasma-Mass Spectrometry 010402 general chemistry Tumor-Cells 01 natural sciences Agent Vitro Inorganic Chemistry Inhibitory Concentration 50 chemistry.chemical_compound In-Vivo Evaluation Fluorescence Microscopy X-Ray Diffraction Nami-A Organometallic Compounds Fluorescence microscope NAMI-A Physical and Theoretical Chemistry Protein Interactions Cellular localization Anthracenes Anthracene 010405 organic chemistry Chemistry Ligand Drugs Hydrogen Bonding Platinum(Ii) Complexes 0104 chemical sciences 3. Good health Ruthenium Spectrometry Fluorescence Microscopy Fluorescence Ruthenium Compounds Intracellular
Zdroj:	Inorganic Chemistry. 51:3633-3639
ISSN:	1520-510X 0020-1669
Popis:	Anthracene derivatives of ruthenium(II) arene compounds with 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane (pta) or a sugar phosphite ligand, viz., 3,5,6-bicyclophosphite-1,2-O-isopropylidene-α-d-glucofuranoside, were prepared in order to evaluate their anticancer properties compared to the parent compounds and to use them as models for intracellular visualization by fluorescence microscopy. Similar IC(50) values were obtained in cell proliferation assays, and similar levels of uptake and accumulation were also established. The X-ray structure of [{Ru(η(6)-C(6)H(5)CH(2)NHCO-anthracene)Cl(2)(pta)] is also reported.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7472d105948edbe2c9580469cc0cc36 https://doi.org/10.1021/ic202530j Zobrazit plný text záznamu