Statistical analysis of data in mutagenicity assays: rodent micronucleus assay
| Autor: | T Sofuni, Y Sakamoto, I Yoshimura, Makoto Hayashi, S Hashimoto, C Hamada |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Male
Micronucleus Tests Mutagenicity Tests Health Toxicology and Mutagenesis Public Health Environmental and Occupational Health Computational biology Biology Toxicology Mice Chemical safety Data Interpretation Statistical Micronucleus test Animals Statistical analysis Monte Carlo Method Research Article |
| Zdroj: | Environmental Health Perspectives |
| ISSN: | 1552-9924 0091-6765 |
| DOI: | 10.1289/ehp.94102s149 |
| Popis: | To evaluate chemical safety, many kinds of short-term mutagenicity assays are performed together with long-term assays in animals. Rationales and methodology for these assays have been well discussed and documented. No statistical method, however, has been singled out as the method of choice for the evaluation of mutagenicity assay data, although a number of reports on statistical methods to evaluate such data have been published. Among the mutagenicity assays, the micronucleus assay using mouse bone marrow erythropoietic cells have been widely used to assess cytogenetic activities of test chemicals. A statistical evaluation procedure for this assay is proposed herein, combining the use of historical control data and dose-response relationships. The probability of type I errors and the power of this method are compared with those of some other conventional methods by Monte Carlo simulation. |
| Databáze: | OpenAIRE |
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