Elevated plasma levels of human urotensin-II immunoreactivity in congestive heart failure
| Autor: | Nick Bett, Andrew J. Galbraith, Fraser D. Russell, Deborah Meyers, Istvan Toth, Peter C. M. Molenaar, Philip Kearns |
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| Předmět: |
Male
medicine.medical_specialty Heart disease Physiology Urotensins Femoral vein Radioimmunoassay Femoral artery Coronary artery disease Physiology (medical) Internal medicine medicine.artery medicine Humans Subtilisins Furin Heart Failure Ischemic cardiomyopathy business.industry Dilated cardiomyopathy Middle Aged medicine.disease Myocardial Contraction Peptide Fragments Heart failure Case-Control Studies Pulmonary artery cardiovascular system Cardiology Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Scopus-Elsevier |
| Popis: | Human urotensin-II (hU-II) is the most potent endogenous cardiostimulant identified to date. We therefore determined whether hU-II has a possible pathological role by investigating its levels in patients with congestive heart failure (CHF). Blood samples were obtained from the aortic root, femoral artery, femoral vein, and pulmonary artery from CHF patients undergoing cardiac catheterization and the aortic root from patients undergoing investigative angiography for chest pain who were not in heart failure. Immunoreactive hU-II (hU-II-ir) levels were determined with radioimmunoassay. hU-II-ir was elevated in the aortic root of CHF patients (230.9 ± 68.7 pg/ml, n = 21; P < 0.001) vs. patients with nonfailing hearts (22.7 ± 6.1 pg/ml, n = 18). This increase was attributed to cardiopulmonary production of hU-II-ir because levels were lower in the pulmonary artery (38.2 ± 6.1 pg/ml, n = 21; P < 0.001) than in the aortic root. hU-II-ir was elevated in the aortic root of CHF patients with nonischemic cardiomyopathy (142.1 ± 51.5 pg/ml, n = 10; P < 0.05) vs. patients with nonfailing hearts without coronary artery disease (27.3 ± 12.4 pg/ml, n = 7) and CHF patients with ischemic cardiomyopathy (311.6 ± 120.4 pg/ml, n = 11; P < 0.001) vs. patients with nonfailing hearts and coronary artery disease (19.8 ± 6.6 pg/ml, n = 11). hU-II-ir was significantly higher in the aortic root than in the pulmonary artery and femoral vein, with a nonsignificant trend for higher levels in the aortic root than in the femoral artery. The findings indicated that hU-II-ir is elevated in the aortic root of CHF patients and that hU-II-ir is cleared at least in part from the microcirculation. |
| Databáze: | OpenAIRE |
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