Clinical, hematological, and biochemical features of Hb SC disease
| Autor: | Cynthia N. Lewis, Edward R. Burka, Samir K. Ballas, Steven H. Krasnow, Ann Marie Noone, Embi Kamarulzaman |
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| Rok vydání: | 1982 |
| Předmět: |
Adult
Male Hemolytic anemia medicine.medical_specialty Asplenia Pathology Adolescent Anemia Hemoglobin Sickle Immunoglobulins Anemia Sickle Cell Renal papillary necrosis Gastroenterology Retinal Diseases Thromboembolism Internal medicine medicine Humans Radionuclide Imaging business.industry Hematology Middle Aged Hemoglobin C Disease medicine.disease Haemolysis Sickle cell anemia Hemoglobinopathy Liver Creatinine Splenomegaly Female Kidney Papillary Necrosis Hemoglobin business Spleen |
| Zdroj: | American Journal of Hematology. 13:37-51 |
| ISSN: | 1096-8652 0361-8609 |
| DOI: | 10.1002/ajh.2830130106 |
| Popis: | Twenty-seven patients were seen and followed at our Sickle Cell Center over a period of seven years. Their clinical, hematological, and biochemical features were determined and compared to those of patients with sickle cell anemia who were concurrently investigated. The data indicate that the mild anemia of hemoglobin (Hb) SC disease is slightly microcytic and hyperchromatic. Parameters of hemolysis and the complications of chronic hemolytic anemia (cholelithiasis, leg ulcers, hepatomegaly, and cardiomegaly) are milder in Hb SC disease than in sickle cell anemia. Asplenia and its sequelae (increased platelet count and reduced serum IgM levels) are less frequent in Hb SC disease. Cerebrovascular accidents and the decreased leukocyte alkaline phosphatase scores are similar in both diseases. Thromboembolic complications, retinopathy, and renal papillary necrosis are more frequent in Hb SC disease. |
| Databáze: | OpenAIRE |
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