Exercise Reduces the Resumption of Tumor Growth and Proteolytic Pathways in the Skeletal Muscle of Mice Following Chemotherapy
| Autor: | Alexandre Abilio de Souza Teixeira, Tiego A. Diniz, Silvia Busquets Rius, Edson A. Lima, Dario Coletti, Loreana Sanches Silveira, Luana A Biondo, José Cesar Rosa Neto |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty tumor Etiology medicine.medical_treatment Myostatin endurance exercise Protein degradation chemotherapy CAQUEXIA lcsh:RC254-282 doxorubicin Article 03 medical and health sciences 0302 clinical medicine Endurance training Internal medicine Quimioteràpia medicine Chemotherapy Doxorubicin skeletal muscle biology business.industry lewis lung carcinoma Lewis lung carcinoma Skeletal muscle 030229 sport sciences lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Muscle atrophy 030104 developmental biology Endocrinology medicine.anatomical_structure Oncology Etiologia biology.protein Càncer de pulmó medicine.symptom Lung cancer business medicine.drug |
| Zdroj: | Cancers Volume 12 Issue 11 Dipòsit Digital de la UB Universidad de Barcelona Cancers, Vol 12, Iss 3466, p 3466 (2020) Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 2072-6694 |
| DOI: | 10.3390/cancers12113466 |
| Popis: | The pathogenesis of muscle atrophy plays a central role in cancer cachexia, and chemotherapy contributes to this condition. Therefore, the present study aimed to evaluate the effects of endurance exercise on time-dependent muscle atrophy caused by doxorubicin. For this, C57 BL/6 mice were subcutaneously inoculated with Lewis lung carcinoma cells (LLC group). One week after the tumor establishment, a group of these animals initiated the doxorubicin chemotherapy alone (LLC + DOX group) or combined with endurance exercise (LLC + DOX + EXER group). One group of animals was euthanized after the chemotherapy cycle, whereas the remaining animals were euthanized one week after the last administration of doxorubicin. The practice of exercise combined with chemotherapy showed beneficial effects such as a decrease in tumor growth rate after chemotherapy interruption and amelioration of premature death due to doxorubicin toxicity. Moreover, the protein degradation levels in mice undergoing exercise returned to basal levels after chemotherapy in contrast, the mice treated with doxorubicin alone experienced an increase in the mRNA expression levels of the proteolytic pathways in gastrocnemius muscle (Trim63, Fbxo32, Myostatin, FoxO). Collectively, our results suggest that endurance exercise could be utilized during and after chemotherapy for mitigating muscle atrophy promoted by doxorubicin and avoid the resumption of tumor growth. |
| Databáze: | OpenAIRE |
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