Effect of treatment with sodium valproate and diazepam on plasma corticotropin in Nelson's syndrome
| Autor: | Victor Wynn, R.R. Abraham, U. Beckford, Mary Seed, Brian Gillham, MortynT. Jones, Anne Dornhorst |
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| Rok vydání: | 1981 |
| Předmět: |
Drug
Adult Male medicine.medical_specialty Sodium media_common.quotation_subject Hypothalamus chemistry.chemical_element Adrenocorticotropic hormone Transaminase Nelson Syndrome Adrenocorticotropic Hormone Internal medicine medicine Humans Pituitary Neoplasms gamma-Aminobutyric Acid media_common Diazepam business.industry Valproic Acid digestive oral and skin physiology Nelson's syndrome General Medicine Middle Aged medicine.disease Endocrinology nervous system chemistry Depression Chemical Female Headaches medicine.symptom business medicine.drug |
| Zdroj: | Lancet (London, England). 1(8231) |
| ISSN: | 0140-6736 |
| Popis: | Six patients with Nelson's syndrome were given sodium valproate with or without diazepam for 3 or 5 weeks. Initial high plasma adrenocorticotropic hormone (ACTH) concentrations were greatly reduced by treatment and returned to high levels when treatment was stopped. Diazepam did not add significantly to the effects of sodium valproate alone. Three patients reported a decrease in the severity and frequency of headaches while on sodium valproate. In five patients abnormal skin pigmentation was reduced. Sodium valproate is a gamma-aminobutyric acid (GABA) transaminase inhibitor and it is suggested that the drug raises GABA levels in the hypothalamus and that this is responsible for the reduction in ACTH secretion. The data are consistent with the hypothesis that Nelson's syndrome is a neuroendocrine disease caused by a deficiency in the hypothalamic GABA-ergic system. |
| Databáze: | OpenAIRE |
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