Positive Resection Margins Detected by Standardized Study of a Pancreaticoduodenectomy Sample: Is there Any Real Impact on Long-term Survival?
| Autor: | Elena Martín-Pérez, Mercedes Guijarro Rojas, Enrique Alday Muñoz, Jose Luis Muñoz de Nova, Marcello Di Martino |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Perineural invasion Gastroenterology Disease-Free Survival Pancreaticoduodenectomy Resection Internal medicine Pancreatic cancer medicine Humans Pathological Aged Retrospective Studies business.industry General Engineering Margins of Excision Middle Aged Prognosis medicine.disease Pancreatic Neoplasms Lymphatic system Resection margin Female Lymph Neoplasm Recurrence Local business Carcinoma Pancreatic Ductal |
| Zdroj: | Cirugía Española (English Edition). 98:127-135 |
| ISSN: | 2173-5077 |
| Popis: | INTRODUCTION The pathological evaluation of pancreaticoduodenectomy (PD) samples and the impact of R1 resections on survival has recently been questioned. This study evaluates the introduction of a standardized pathology study protocol (PSP) and the prognosis of R1 resections after long-term follow-up. METHODS We reviewed data from a prospectively maintained database regarding 109 periampullary tumors treated by PD from 2005 to 2013. The results of the introduction of a PSP were analysed, and the recurrence rate (RR), disease-free survival (DFS) and overall survival (OS) of the R1 resections were evaluated for each positive margin. RESULTS The PD specimens of periampullary tumors analyzed by PSP showed a higher rate of isolated lymph nodes (17 vs. 8; P=.003), N+ (60% vs. 31%; P |
| Databáze: | OpenAIRE |
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