Pancreas Donor Risk Index and Preprocurement Pancreas Suitability Score for Prediction of Pancreas Transplant Outcomes
| Autor: | Argiris Asderakis, Doruk Elker, Aeliya Zaidi, Usman Khalid, Elijah Ablorsu, Ky-Leigh Ang, Mohamed A. Ilham |
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| Rok vydání: | 2021 |
| Předmět: |
Graft Rejection
Transplantation medicine.medical_specialty education.field_of_study Graft rejection business.industry Graft Survival Population Patient survival Gastroenterology Tissue Donors Treatment Outcome medicine.anatomical_structure Full data Internal medicine Risk index medicine Humans Pancreas Transplantation business education Pancreas Hospital stay Retrospective Studies |
| Zdroj: | Experimental and Clinical Transplantation. 19:1197-1203 |
| ISSN: | 2146-8427 1304-0855 |
| Popis: | The Pancreas Donor Risk Index and Preprocurement Pancreas Suitability Score were designed to assist in the evaluation of pancreases for transplant. Preprocurement Pancreas Suitability Score17 and PancreasDonor Risk Index ≤1.57 were deemed ideal.We aimed to determine the ability ofthese scores to predict pancreas transplant outcomes.The Pancreas Donor Risk Index and the Preprocurement Pancreas Suitability Score were retrospectively calculated from a prospectively maintained database of consecutive pancreas transplants performed during a 13-year period (December 2004 to November 2017). Outcomes measuredwere rejection rate, graft and patient survival, and duration of hospital stay.Of 159 pancreas transplants (108 simultaneous pancreas and kidney transplants, 33 pancreas after kidney transplants, 18 pancreas-only transplants), full data were available for 155 (97%) to calculate Pancreas Donor Risk Indexes and 129 (81%) to calculate Preprocurement Pancreas Suitability Scores. Fortyseven patients (30%) experienced at least 1 episode of acute rejection. We calculated Pancreas Donor Risk Indexes for 155 patients, and 19 (23%) and 27 (38%) were in the ≤1.57 and1.57 groups, respectively (P = .047). We calculated Preprocurement Pancreas Suitability Scores for 129 patients, and 12 (21%) and 27 (32%) were in the17 and ≥17 groups, respectively (P = .202). Donor age and recipientfemale sex were the main predictors forrejection (binary logistic regression, P.05). One-year graft survival rates were 95% and 81% forthe ≤1.57 and1.57 PancreasDonor Risk Index groups,respectively, and 95% and 80% forthe17 and ≥17 Preprocurement Pancreas Suitability Score groups, respectively (not significant).Pancreas Donor Risk Index and Preprocurement Pancreas Suitability Score were not helpful to predict graft/patient survival in our population. A higher Pancreas Donor Risk Index was associated with higher risk of graft rejection. Further studies with larger cohorts are required. |
| Databáze: | OpenAIRE |
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