Renal and testicular up-regulation of pro-inflammatory chemokines (RANTES and CCL2) and cytokines (TNF-α, IL-1β, IL-6) following acute edible camphor administration is through activation of NF-kB in rats
| Autor: | Oluwaseyi A. Safiriyu, Oluwatobi T. Somade, Oluwasola S. Oyabunmi, Adio Jamiu Akamo, Babajide O. Ajayi |
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| Rok vydání: | 2019 |
| Předmět: |
Chemokine
medicine.medical_specialty Health Toxicology and Mutagenesis 010501 environmental sciences CCL2 Toxicology 01 natural sciences Article 03 medical and health sciences Camphor chemistry.chemical_compound 0302 clinical medicine lcsh:RA1190-1270 Internal medicine Medicine Renal Interleukin 6 lcsh:Toxicology. Poisons 0105 earth and related environmental sciences Kidney biology business.industry Interleukin 10 Endocrinology medicine.anatomical_structure chemistry Pro-inflammation biology.protein Cytokines Testicular Tumor necrosis factor alpha Cyclooxygenase Chemokines business 030217 neurology & neurosurgery |
| Zdroj: | Toxicology Reports Toxicology Reports, Vol 6, Iss, Pp 759-767 (2019) |
| ISSN: | 2214-7500 |
| DOI: | 10.1016/j.toxrep.2019.07.010 |
| Popis: | Camphor-induced oxidative stress and histopathological changes (in brain, lung, liver, kidney and testes) have been reported. We therefore investigated the effect of various doses of camphor in an acute study, on renal and testicular levels of some pro-inflammatory mediators in male wistar rats. Twenty rats divided into four groups of five rats each were used in this study. Group 1 served as control and was administered 6 mL/kg olive oil, the vehicle for camphor, while groups 2, 3 and 4 were orally administered 1000, 2000, and 4000 mg/kg body weight camphor, for seven days. Compared with control, levels of tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β) and interleukin 6 (IL-6) were significantly increased kidney and testes by 2000 and 4000 mg/kg body weight, while interleukin 10 (IL-10) was only significantly increased by 1000 mg/kg body weight of camphor in both tissues. Also compared with control, all doses of camphor administered resulted in a significant increase in the expressions of renal and testicular nuclear factor kappa B (NFkB), cyclooxygenase 2 (COX-2), regulated upon activation normal T cell expressed and secreted (RANTES), and monocyte chemo-attractant protein 1 (MCP-1). Conclusively, use and consumption of camphor should be with caution as it could trigger renal and testicular inflammation through activation of NF-kB and up-regulation of pro-inflammatory markers. Keywords: Camphor, Chemokines, Cytokines, Pro-inflammation, Renal, Testicular |
| Databáze: | OpenAIRE |
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