Influence of Starvation and Glucose Load on the Activity of Liver Phosphorylase in Normal and Adrenalectomized Rats
| Autor: | N. Schwartz Sørensen |
|---|---|
| Rok vydání: | 1957 |
| Předmět: |
medicine.medical_specialty
Phosphorylases Phosphatase Glucagon Glycogen phosphorylase chemistry.chemical_compound Internal medicine medicine Animals chemistry.chemical_classification Starvation Multidisciplinary Chemistry Phosphate Rats Leadership Glucose Liver metabolism Endocrinology Epinephrine Enzyme Liver Biochemistry medicine.symptom medicine.drug |
| Zdroj: | Nature. 180:857-858 |
| ISSN: | 1476-4687 0028-0836 |
| Popis: | RECENTLY, it has been shown by Sutherland et al.1,2 that liver phosphorylase is acted on by two different enzymes. They found that the inactivation of liver phosphorylase was caused by an enzyme which appeared to be a phosphatase able to split off phosphate from active liver phosphorylase and thus render it inactive. Furthermore, they were able to demonstrate the existence of another enzyme able to reactivate inactive phosphorylase. In an earlier work, Sutherland and Cori3 showed that epinephrine and glucagon play an essential part in the activation of liver phosphorylase, and evidence has since been established for the assumption that epinephrine and glucagon are reacting in some way or other with the reactivating enzyme. The complete mechanism has not yet been worked out, although a recent paper published by Rail, Sutherland and Berthet4 has elicited the problem further. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|