Examining the Relationship Between Gastroschisis and Placental Fetal Vascular Malperfusion
| Autor: | Ahmed Nasr, Sarah Lawrence, Brittany Ruschkowski, Irina Oltean, Dina El Demellawy |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty Placenta Diseases placenta Original Investigations Pathology and Forensic Medicine neonatal Pathogenesis 03 medical and health sciences Fetus 0302 clinical medicine vascular Pregnancy Basic research basic research Placenta medicine Humans Retrospective Studies teratology Gastroschisis 030219 obstetrics & reproductive medicine business.industry Abdominal wall defect Infant Newborn dysmorphology General Medicine fetal medicine.disease GI Teratology medicine.anatomical_structure clinical neonatology 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health microscopy Female business |
| Zdroj: | Pediatric and Developmental Pathology |
| ISSN: | 1615-5742 1093-5266 |
| Popis: | Introduction Gastroschisis is a congenital malformation characterized by intestinal herniation through an abdominal wall defect. Despite its unknown pathogenesis, known risk factors include maternal smoking, alcohol use, and young maternal age. Previous work has shown that gastroschisis is associated with placental delayed villous maturation, and the goal of this study was to assess for additional associated placental pathologies that may help clarify the pathogenesis of gastroschisis. Methods We conducted a retrospective slide review of 29 placentas of neonates with gastroschisis. Additionally, we reviewed pathology reports from one control group of 30 placentas with other congenital malformations. Gross and histological data were collected based on a standardized rubric. Results Gastroschisis was associated with increased placental fetal vascular malperfusion (FVM) in 62% of cases (versus 0% of controls, p Conclusion Our study demonstrates an association between gastroschisis and FVM. While FVM could be the consequence of vascular disruption due to the ventral location of gastroschisis, it could also reflect estrogen-induced thrombosis in early pregnancy. Further research is needed to separate these possibilities and determine the cause of the placental FVM observed in gastroschisis. |
| Databáze: | OpenAIRE |
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