A new strategy to tackle severe knee osteoarthritis: Combination of intra-articular and intraosseous injections of Platelet Rich Plasma
| Autor: | Gorka Orive, Roberto Prado, Diego Delgado, Mikel Sánchez, Eduardo Anitua, Peio Sanchez, Juan Jose Goiriena, Sabino Padilla, Felipe Prosper |
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| Rok vydání: | 2016 |
| Předmět: |
musculoskeletal diseases
0301 basic medicine Cellular data Pathology medicine.medical_specialty Knee Joint Clinical Biochemistry Articular cartilage Osteoarthritis Injections Intra-Articular 03 medical and health sciences 0302 clinical medicine Intra articular Drug Discovery Medicine Humans 030203 arthritis & rheumatology Pharmacology business.industry Platelet-Rich Plasma Tissue level Osteoarthritis Knee musculoskeletal system medicine.disease Infusions Intraosseous 030104 developmental biology medicine.anatomical_structure Subchondral bone Platelet-rich plasma Intercellular Signaling Peptides and Proteins Synovial membrane business |
| Zdroj: | Expert opinion on biological therapy. 16(5) |
| ISSN: | 1744-7682 |
| Popis: | Knee osteoarthritis (KOA) is a mechanically induced, cytokine and enzyme-mediated disorder involving all the joint tissue of the knee. Rebuilding a physiological-homeostatic network at the tissue level following knee organ failure, such as in severe KOA, is a daunting task with therapeutic targets encompassing the articular cartilage, synovium and subchondral bone. Intraarticular infiltration of plasma rich in growth factors (PRP) has emerged as a promising symptomatic approach, although it is insufficient to reach the subchondral bone.This review addresses current molecular and cellular data in joint homeostasis and osteoarthritis pathophysiology. In particular, it focuses on changes that subchondral bone undergoes in knee osteoarthritis and evaluates recent observations on the crosstalk among articular cartilage, subchondral bone and synovial membrane. In addition, we review some mechanistic aspects that have been proposed and provide the rationale for using PRP intraosseously in KOA.The knee joint is a paradigm of autonomy and connectedness of its anatomical structures and tissues from which it is made. We propose an innovative approach to the treatment of severe knee osteoarthritis consisting of a combination of intraarticular and intraosseous infiltrations of PRP, which might offer a new therapeutic tool in KOA therapy. |
| Databáze: | OpenAIRE |
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