Cardiovascular Risk Indices and Their Impact on Outcome in Patients with Hyperglycaemic Emergencies in a Nigerian Hospital
| Autor: | Rosemary Ikem, Babatope Kolawole, Olaoluwatomi Yusuff, O O Amjo, David Soyoye |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Waist Respiratory rate Cross-sectional study Cardiovascular risk factors Nigeria Disease Risk Factors Internal medicine Plasminogen Activator Inhibitor 1 Humans Medicine In patient Correlation of Data Cause of death business.industry General Medicine Middle Aged medicine.disease C-Reactive Protein Cross-Sectional Studies Cardiovascular Diseases Heart Disease Risk Factors Hyperglycemia Female Microalbuminuria Emergencies business |
| Zdroj: | Journal of the National Medical Association. 112:28-35 |
| ISSN: | 0027-9684 |
| DOI: | 10.1016/j.jnma.2019.12.004 |
| Popis: | Background High sensitivity C-reactive protein (hsCRP) and Plasminogen Activator Inhibitor-1 (PAI-1) are recognised independent novel risk factors for cardiovascular disease. Few studies have assessed cardiovascular risk factors in patients with hyperglycaemic emergencies (HE), despite it being a major cause of death in diabetics. Objective The objective of this study was to determine cardiovascular risk indices in patients with hyperglycaemic emergencies and related these with outcome. Methods This cross sectional study involved 45 patients that presented with HE and 45 age and sex matched diabetics without HE who served as controls. Historical features, physical findings and laboratory parameters including hsCRP and PAI-1 were compared between subjects and controls. Results The mean values of serum hsCRP and PAI-1 were significantly higher in patients with HE compared to diabetic control. (49.52 ± 13.6 vs. 2.4 ± 1.35, 51.2 ± 28.7 vs. 33.2 ± 10.7 respectively). Traditional cardiovascular risk factors such as HbA1c, Atherogenic Index and microalbuminuria were also significantly higher in them. Mortality was associated with increasing age, higher values of waist circumference, pulse rate, respiratory rate, hsCRP, Atherogenic index and lower blood pressure and HDL values. Conclusion Cardiovascular risk indices are higher in patients with HE. |
| Databáze: | OpenAIRE |
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