Inflammation exacerbates seizure-induced injury in the immature brain
| Autor: | Justin Miyamoto, Don Shin, Stéphane Auvin, Raman Sankar, JoAnne Nakagawa, Andrey Mazarati |
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| Rok vydání: | 2007 |
| Předmět: |
Lipopolysaccharides
Male medicine.medical_specialty Kainic acid Central nervous system Hippocampus Inflammation Cell Count Status epilepticus Hippocampal formation Body Temperature chemistry.chemical_compound Epilepsy Status Epilepticus Seizures Internal medicine medicine Animals Rats Wistar Neurons business.industry Pilocarpine Brain medicine.disease Rats Disease Models Animal Endocrinology medicine.anatomical_structure nervous system Neurology chemistry Animals Newborn Acute Disease Female Neurology (clinical) medicine.symptom business Neuroscience medicine.drug |
| Zdroj: | Epilepsia. 48 |
| ISSN: | 0013-9580 |
| Popis: | We examined the hypothesis that the introduction of an inflammatory agent would augment status epilepticus (SE)-induced neuronal injury in the developing rat brain in the absence of an increase in body temperature. Postnatal day 7 (P7) and P14 rat pups were injected with an exogenous provocative agent of inflammation, lipopolysaccharide (LPS), 2 h prior to limbic SE induced by either lithium-pilocarpine (LiPC) or kainic acid. Core temperature was recorded during the SE and neuronal injury was assessed 24 h later using profile cell counts in defined areas of the hippocampus. While LPS by itself did not produce any discernible cell injury at either age, it exacerbated hippocampal damage induced by seizures. In the LiPC model, this effect was highly selective for the CA1 subfield, and there was no concomitant rise in body temperature. Our findings show that inflammation increases the vulnerability of immature hippocampus to seizure-induced neuronal injury and suggest that inflammation might be an important factor aggravating the long-term outcomes of seizures occurring early in life. |
| Databáze: | OpenAIRE |
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