The Cloning of a Family of Genes That Encode the Melanocortin Receptors
| Autor: | Roger D. Cone, Kathleen G. Mountjoy, Linda S. Robbins, Marty Mortrud |
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| Rok vydání: | 1992 |
| Předmět: |
endocrine system
medicine.medical_specialty Molecular Sequence Data Class C GPCR Immune receptor Biology Polymerase Chain Reaction Rhodopsin-like receptors Mice Melanocortin receptor GTP-Binding Proteins Sequence Homology Nucleic Acid Internal medicine medicine Animals Humans ACTH receptor Amino Acid Sequence Melanocyte-Stimulating Hormones RNA Messenger Receptors Pituitary Hormone Cloning Molecular Receptor Multidisciplinary Dose-Response Relationship Drug Blotting Northern Cell biology Endocrinology Receptors Corticotropin Hormone receptor Adrenal Cortex Melanocytes Melanocortin hormones hormone substitutes and hormone antagonists |
| Zdroj: | Science. 257:1248-1251 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.1325670 |
| Popis: | Melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH) regulate pigmentation and adrenal cortical function, respectively. These peptides also have a variety of biological activities in other areas, including the brain, the pituitary, and the immune system. A complete understanding of the biological activities of these hormones requires the isolation and characterization of their corresponding receptors. The murine and human MSH receptors (MSH-Rs) and a human ACTH receptor (ACTH-R) were cloned. These receptors define a subfamily of receptors coupled to guanine nucleotide-binding proteins that may include the cannabinoid receptor. |
| Databáze: | OpenAIRE |
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