Transient Ischemic Dilation in Patients With Diabetes Mellitus
| Autor: | Wanda Acampa, Mario Petretta, Monica Plaitano, Maria Piera Petretta, Stefania Daniele, Alberto Cuocolo |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Time Factors medicine.medical_treatment Myocardial Ischemia Ischemia Revascularization Risk Assessment Ventricular Function Left Myocardial perfusion imaging Risk Factors Internal medicine Myocardial Revascularization medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies Myocardial infarction Aged Tomography Emission-Computed Single-Photon Ejection fraction medicine.diagnostic_test business.industry Proportional hazards model Incidence Hazard ratio Middle Aged myocardial perfusion imaging Transient Ischemic Dilation medicine.disease Death Sudden Cardiac Diabetes Mellitus Type 2 Italy diabetes mellitus Cardiology Female prognosis Cardiology and Cardiovascular Medicine business Follow-Up Studies |
| Zdroj: | Circulation. Cardiovascular imaging 6 (2013): 908–915. doi:10.1161/CIRCIMAGING.113.000497 info:cnr-pdr/source/autori:Petretta, Mario; Acampa, Wanda; Daniele, Stefania; Petretta, Maria Piera; Plaitano, Monica; Cuocolo, Alberto/titolo:Transient Ischemic Dilation in Patients With Diabetes Mellitus Prognostic Value and Effect on Clinical Outcome After Coronary Revascularization/doi:10.1161%2FCIRCIMAGING.113.000497/rivista:Circulation. Cardiovascular imaging/anno:2013/pagina_da:908/pagina_a:915/intervallo_pagine:908–915/volume:6 |
| ISSN: | 1942-0080 1941-9651 |
| Popis: | Background— We prospectively evaluated the incremental prognostic value of transient ischemic dilation (TID) in patients with type 2 diabetes mellitus during long-term follow-up and estimated cardiac death and nonfatal myocardial infarction (MI) using traditional approaches of prognostication to more recent methods. Methods and Results— A total of 672 consecutive diabetic patients with available rest and stress gated myocardial perfusion single-photon emission computed tomographic data were enrolled. Stepwise Cox regression analysis was used to estimate cardiac death or nonfatal MI. Risk reclassification was calculated, and an exploratory analysis was performed to evaluate the effect of coronary revascularization on event-free survival. Adding TID to a multivariable model, including age, history of MI, stress type, poststress left ventricular ejection fraction, and stress-induced myocardial ischemia, improved discrimination of cardiac death or nonfatal MI (C statistic, 0.74–0.82; P =0.01; adjusted hazard ratio, 3.6; P P P Conclusions— TID provides independent and incremental prognostic information for the prediction of cardiac death or nonfatal MI in patients with diabetes mellitus. The addition of TID to a prediction model based on cardiovascular risk factors, left ventricular ejection fraction, and ischemia significantly improves risk discrimination and reclassification for incident cardiac events. The effect of revascularization seems to be influenced by left ventricular systolic function, stress-induced myocardial ischemia, and TID. |
| Databáze: | OpenAIRE |
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