Association of VEGF Gene Polymorphisms with the Risk and Prognosis of Cutaneous Squamous Cell Carcinoma
| Autor: | Li Zhang, Xiao-juan Nie, Wen-min Liu |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male Vascular Endothelial Growth Factor A medicine.medical_specialty China Single-nucleotide polymorphism Biology Gastroenterology Polymorphism Single Nucleotide 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Gene Frequency Clinical Research Internal medicine Genotype medicine Carcinoma Humans Genetic Predisposition to Disease Allele Allele frequency Alleles Genetic Association Studies Polymorphism Single-Stranded Conformational Aged Case-control study General Medicine Middle Aged medicine.disease Prognosis Vascular endothelial growth factor 030104 developmental biology chemistry 030220 oncology & carcinogenesis Case-Control Studies Cancer research Carcinoma Squamous Cell Female Vascular Endothelial Growth Factor Endocrine-Gland-Derived Skin cancer |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1643-3750 |
| Popis: | Background Cutaneous squamous cell carcinoma (cSCC) is the second most common type of non-melanoma skin cancer (NMSC) globally. The aims of this study were to further systematically clarify the potential association of rs833061 (-460 C>T) and rs1570360 (-1154 G>A), two SNPs of VEGF, with the risk of cSCC and the prognostic impacts on cSCC patients. Material/Methods This hospital-based case-control study analyzed peripheral venous blood collected from 100 cSCC patients and 124 healthy controls, and gathered personal information on patients. Genotypes of the VEGF gene -460C>T and -1154G>A polymorphism were detected using polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) method. Different distributions of allele frequencies and genotype in the case and control group were measured, comparing different genotype differences in the survival of patients with cSCC. Results Distributions of allele frequencies and genotype of -460 C>T in the case and control group were statistically different; the TT + CT genotype was significantly correlated with a decrease risk of cSCC (OR=0.36, 95% CI=0.21–0.63, PA between control and case groups. For -1154460C>T, the CC genotype was an adverse factor, associated with a significant decrease in the survival status of cSCC patients (PA, the AA genotype was significantly correlated with the reduced overall survival in cSCC patients, with the mean survival time of 23.88 months (P=0.009). Conclusions The VEGF gene -460 C>T polymorphism and -1154 G>A polymorphism may serve as potential genetic markers for the risk and prognosis of cSCC. |
| Databáze: | OpenAIRE |
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