Interaction between warfarin and propafenone in healthy volunteer subjects
| Autor: | Edward B Kirsten, Yin-Gail Yee, Robert E. Kates |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
Male medicine.drug_class Propafenone Pharmacology law.invention Pharmacokinetics Reference Values law medicine Humans Drug Interactions heterocyclic compounds Pharmacology (medical) cardiovascular diseases Volunteer Prothrombin time Clinical pharmacology medicine.diagnostic_test business.industry Anticoagulant Warfarin Drug interaction Kinetics Anesthesia Prothrombin Time business Protein Binding medicine.drug |
| Zdroj: | Clinical Pharmacology and Therapeutics. 42:305-311 |
| ISSN: | 1532-6535 0009-9236 |
| DOI: | 10.1038/clpt.1987.152 |
| Popis: | The effect of propafenone on the pharmacokinetics and pharmacologic effects of warfarin was studied in healthy normal male volunteer subjects. Each drug was administered alone for 1 week followed by a combined administration for 1 additional week. Blood samples were analyzed for propafenone and warfarin concentrations and the effect of each treatment on the prothrombin time was assessed. The concurrent administration of warfarin did not produce any changes in the absorption or disposition kinetics of propafenone. Concurrent propafenone administration did lead to a reduction in the clearance of warfarin, resulting in an average increase of 38% in the mean steady-state plasma warfarin concentration. During the combined therapy phase, the prothrombin time increased significantly (P < 0.01) from the “warfarin alone” phase. We conclude from this study that the concomitant administration of propafenone and warfarin may lead to an enhanced anticoagulant effect that may require a reduction in the warfarin dose. Clinical Pharmacology and Therapeutics (1987) 42, 305–311; doi:10.1038/clpt.1987.152 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text