Significance of arterial ketone body ratio measurement in human liver transplantation
| Autor: | Martin Burdelski, Yoshio Yamaoka, Hartwig Bunzendahl, Kazue Ozawal, Ryoji Okamoto, B. Ringe, Pichlmayr R, Albrecht Bornscheuer, Yoshiro Taki, Yuzo Yamamoto, Michael Oellerich, Gundolf Gubernatis, Margrit Beneking |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment Urology Ketone Bodies Liver transplantation Group A Group B Medicine Humans Aspartate Aminotransferases Ratio measurement Transplantation Human liver business.industry Alanine Transaminase Bilirubin Prognosis Surgery Liver Transplantation Perfusion Liver Ketone bodies Lactates Arterial blood Partial Thromboplastin Time business |
| Zdroj: | Transplantation. 49(3) |
| ISSN: | 0041-1337 |
| Popis: | Arterial ketone body ratio (KBR), which reflects the NAD+/NADH ratio of hepatic mitochondria, was measured sequentially in 39 liver transplantations. In 22 cases, KBR was increased to above 0.7 within 6 hr after reperfusion (group A). In 11 cases, restoration of KBR was delayed until the first postoperative day (group B) and in 6 cases, KBR failed to recover (group C). The patients in group A survived liver transplantation without complications. By contrast, morbidity and mortality were significantly higher in groups B and C. In 2 cases in group C, the livers were clinically diagnosed as initially nonfunctioning grafts and the patients underwent retransplantation. Another two died of hepatic failure soon after the operation. It is suggested that delayed recovery of KBR is an early indicator of metabolic overload in the liver allograft, and that a delay exceeding 24 hr may imply the need for retransplantation. |
| Databáze: | OpenAIRE |
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