DNA vaccines against the human papillomavirus type 16 E6 or E7 oncoproteins
| Autor: | Wynetta Giles-Davis, Anthony P Wlazlo, Hildegund C. J. Ertl, Hongying Deng |
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| Rok vydání: | 2004 |
| Předmět: |
Cancer Research
Protective immunity Time Factors Papillomavirus E7 Proteins Genetic Vectors Priming (immunology) Biology Cancer Vaccines Adenoviridae Cell Line DNA vaccination Viral vector Mice Antigen Neoplasms Vaccines DNA Animals Humans Papillomavirus Vaccines Human papillomavirus Molecular Biology Mice Inbred BALB C DNA Oncogene Proteins Viral Virology Mice Inbred C57BL Repressor Proteins Vaccination COS Cells Cytokines Interleukin-2 Molecular Medicine Peptides Baculoviridae Spleen Intracellular |
| Zdroj: | Cancer Gene Therapy. 11:457-464 |
| ISSN: | 1476-5500 0929-1903 |
| DOI: | 10.1038/sj.cgt.7700723 |
| Popis: | DNA vaccines expressing the E6 or E7 oncoproteins of human papilloma virus type 16 (HPV-16) in either their wild-type form or fused to sequences that affect intracellular trafficking were tested for induction of protective immunity against tumor cell challenge in two models based on BALB/c and C57Bl/6 mice. The DNA vaccines to E7 gave uniformly disappointing results, while the DNA vaccine that expressed E6 linked to a viral leader sequence protected BALB/c mice against tumor cell challenge given before or after vaccination. The efficacy of this vaccine could be enhanced by a DNA vector prime/viral vector boost regimen. In contrast, priming of mice with the DNA vaccines to E7 reduced the efficacy of a viral vector expressing the same antigen. |
| Databáze: | OpenAIRE |
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