Metabolite Profile and In Vitro Beneficial Effects of Black Garlic (Allium sativum L.) Polar Extract
| Autor: | Paola Bontempo, Lucia Altucci, Sonia Piacente, Anna Maria Molinari, Stefania Lama, Paola Stiuso, Assunta Napolitano, Luigi De Masi, Daniela Rigano |
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| Přispěvatelé: | Bontempo, P., Stiuso, P., Lama, S., Napolitano, A., Piacente, S., Altucci, L., Molinari, A. M., De Masi, L., Rigano, D. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Myeloid
Antioxidant medicine.medical_treatment Metabolite Saponin Cancer cell Tandem mass spectrometry Plant Roots Antioxidants Ingredient chemistry.chemical_compound Tandem Mass Spectrometry TX341-641 Spices Polysaccharide Chromatography High Pressure Liquid chemistry.chemical_classification Chromatography Nutrition and Dietetics Leukemia Traditional medicine Phenylpropanoid Chemistry secondary metabolites food and beverages U937 Cells Black garlic Cancer cells Cellular bioactivity LC-ESI/LTQOrbitrap/MS/MS Methanol extract Secondary metabolites Garlic Humans Leukemia Myeloid Acute Peptides Plant Extracts Polysaccharides Saponins Sulfur Spice High Pressure Liquid Peptide black garlic Human cellular bioactivity Acute Article Plant Extract Secondary metabolite Functional food medicine methanol extract Nutrition. Foods and food supply Plant Root Allium sativum cancer cells Food Science |
| Zdroj: | Nutrients, Vol 13, Iss 2771, p 2771 (2021) Nutrients 13 (2021): 2771. doi:10.3390/nu13082771 info:cnr-pdr/source/autori:Bontempo, Paola; Stiuso, Paola; Lama, Stefania; Napolitano, Assunta; Piacente, Sonia; Altucci, Lucia; Molinari, Anna Maria; De Masi, Luigi; Rigano, Daniela/titolo:Metabolite profile and in vitro beneficial effects of black garlic (Allium sativum L.) polar extract/doi:10.3390%2Fnu13082771/rivista:Nutrients/anno:2021/pagina_da:2771/pagina_a:/intervallo_pagine:2771/volume:13 Nutrients Volume 13 Issue 8 |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu13082771 |
| Popis: | Over the centuries, humans have traditionally used garlic (Allium sativum L.) as a food ingredient (spice) and remedy for many diseases. To confirm this, many extensive studies recognized the therapeutic effects of garlic bulbs. More recently, black garlic (BG), made by heat-ageing white garlic bulbs, has increased its popularity in cuisine and traditional medicine around the world, but there is still limited information on its composition and potential beneficial effects. In this study, the metabolite profile of methanol extract of BG (BGE) was determined by high-performance liquid chromatography coupled to tandem mass spectrometry in high-resolution mode. Results allowed to establish that BGE major components were sulfur derivatives, saccharides, peptides, organic acids, a phenylpropanoid derivative, saponins, and compounds typical of glycerophospholipid metabolism. Characterization of the BGE action in cancer cells revealed that antioxidant, metabolic, and hepatoprotective effects occur upon treatment as well as induction of maturation of acute myeloid leukemia cells. These results are interesting from the impact point of view of BG consumption as a functional food for potential prevention of metabolic and tumor diseases. |
| Databáze: | OpenAIRE |
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