LC-MS/MS measurement of ampicillin residue in swine tissues at 5 days after in-feed administration
| Autor: | Kouko, Hamamoto, Yasuharu, Mizuno |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Pharmacology medicated feed General Veterinary Swine residue level 010401 analytical chemistry 02 engineering and technology Kidney Note 021001 nanoscience & nanotechnology Animal Feed 01 natural sciences Drug Residues 0104 chemical sciences swine tissue LC–MS/MS Tandem Mass Spectrometry ampicillin Animals Female Intestinal Mucosa Muscle Skeletal 0210 nano-technology Chromatography Liquid |
| Zdroj: | The Journal of Veterinary Medical Science |
| ISSN: | 1347-7439 0916-7250 |
| DOI: | 10.1292/jvms.14-0367 |
| Popis: | We assessed ampicillin (ABPC) concentrations of kidney, muscle and intestine after a 5–day withdrawal period in 2 male and a female young Large White pigs fed the diet containing ABPC (ABPC medicated feed, 24 mg/kg/day) for a week. The ABPC residues were measured with liquid chromatography–tandem mass spectrometry, and the mean recoveries and quantitation limits ranged from 91.8 to 97.2% and from 0.1 to 0.12 ng/g, respectively. The residual ABPC concentrations were ≤1.18 ng/g for the muscle, ≤0.53 ng/g for the kidney and ≤1.93 ng/g for the intestine, suggesting below the Japanese provisional maximum residue limits. These results reveal that the analytical method is developed for residual ABPC and that the withdrawal period is appropriate. |
| Databáze: | OpenAIRE |
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