EVALUATION OF PANBIO RAPID ANTIGEN TEST FOR SARS-CoV-2 IN SYMPTOMATIC PATIENTS AND THEIR CONTACTS: A MULTICENTER STUDY
| Autor: | Ana Coeto-Cano, Eduardo Becerril-Vargas, Arturo Galindo-Fraga, Jesús Sepúlveda-Delgado, José Rogelio Pérez-Padilla, Isabel Villegas-Mota, Dora Patricia Cornejo-Juarez, Santiago Ávila-Ríos, Patricia Meza-Meneses, Simon Kawa-Karasik, Rosario Fernández-Plata, Gustavo Reyes-Terán, Thierry Hernández-Gilsoul, Selene Guerrero-Zúñiga, Alexandra Arias-Mendoza, Ireri Thirión-Romero, Joel A. Vazquez-Perez, Tit Midori Pérez-Kawabe, Darwin Stalin Torres-Erazo |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Adult medicine.medical_specialty Abbott Coronavirus disease 2019 (COVID-19) Point-of-care testing Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Infectious and parasitic diseases RC109-216 Sensitivity and Specificity Article Panbio COVID-19 Testing Internal medicine Medicine Humans rapid antigen test Antigens Viral business.industry SARS-CoV-2 COVID-19 General Medicine Middle Aged medicine.disease Comorbidity Test (assessment) Infectious Diseases Cross-Sectional Studies Multicenter study Rapid antigen test point of care test PanbioTM business Viral load |
| Zdroj: | International Journal of Infectious Diseases International Journal of Infectious Diseases, Vol 113, Iss, Pp 218-224 (2021) |
| ISSN: | 1878-3511 1201-9712 |
| Popis: | Background Point-of-care rapid tests to identify SARS-CoV-2 can have clinical benefits. Methods A cross-sectional study in adults visiting emergency services or screening sites of referral hospitals for COVID-19 to validate the diagnostic performance of a rapid antigen test for SARS-CoV-2 (Abbott's Panbio) compared with reverse transcription-polymerase chain reaction (RT-PCR) testing. Tests were performed by health personnel in a routine situation during a COVID-19 outbreak. Results A total of 1060 participants (mean age 47, 46% with a self-reported comorbidity) were recruited from 8 hospitals in Mexico. Participants provided 1060 valid Panbio rapid test-RT-PCR test pairs with 45% testing positive in the RT-PCR. Overall sensitivity of the Panbio test was 54.2% (95% CI 51%–57%), and 69.1% (95% CI 66%–73%) for patients during the first week of symptoms. Sensitivity depended on viral load (cycle threshold (Ct) of RT-PCR) and days of symptoms. With a Ct ≤25, sensitivity was 82% (95% CI, 76%–87%). Specificity of the Panbio test was >97.8% in all groups. Conclusions The Panbio rapid antigen test for SARS-CoV-2 had good specificity but low sensitivity. A negative test requires confirmation with RT-PCR, especially for testing after the first week of symptoms. |
| Databáze: | OpenAIRE |
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