Tissue immunometabolism: development, physiology, and pathobiology
| Autor: | Ajay Chawla, Kevin Man, Vassily I. Kutyavin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Stromal cell Physiology Morphogenesis Adipose tissue Biology Models Biological Article 03 medical and health sciences Immune system Metabolic Diseases Parenchyma Specialization (functional) medicine Animals Humans Molecular Biology Vantage point Cell Biology Cell biology 030104 developmental biology Adipose Tissue Liver Function (biology) |
| Popis: | Evolution of metazoans resulted in the specialization of cellular and tissue function. This was accomplished by division of labor, which allowed tissue parenchymal cells to prioritize their core functions while ancillary functions were delegated to tissue accessory cells, such as immune, stromal, and endothelial cells. In metabolic organs, the accessory cells communicate with their clients, the tissue parenchymal cells, to optimize cellular processes, allowing organisms to adapt to changes in their environment. Here, we discuss tissue immunometabolism from this vantage point, and use examples from adipose tissues (white, beige, and brown) and liver to outline the general principles by which accessory cells support metabolic homeostasis in parenchymal cells. A corollary of this model is that disruption of communication between client and accessory cells might predispose metabolic organs to the development of disease. |
| Databáze: | OpenAIRE |
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