Nanoparticles to Target and Treat Macrophages:The Ockham's Concept?
| Autor: | Alazne Moreno-Lanceta, Mireia Medrano-Bosch, Pedro Melgar-Lesmes |
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| Rok vydání: | 2021 |
| Předmět: |
Macròfags
Phagocytosis Pharmaceutical Science Nanoparticle Spleen Inflammation Review Pharmacy and materia medica medicine Macrophage cancer Nanopartícules Chemistry Regeneration (biology) Macrophages Mononuclear phagocyte system Inflamació Cell biology macrophages RS1-441 medicine.anatomical_structure inflammation regeneration Nanoparticles nanoparticles medicine.symptom Function (biology) |
| Zdroj: | Dipòsit Digital de la UB Universidad de Barcelona Pharmaceutics Pharmaceutics, Vol 13, Iss 1340, p 1340 (2021) |
| Popis: | Nanoparticles are nanomaterials with three external nanoscale dimensions and an average size ranging from 1 to 1000 nm. Nanoparticles have gained notoriety in technological advances due to their tunable physical, chemical, and biological characteristics. However, the administration of functionalized nanoparticles to living beings is still challenging due to the rapid detection and blood and tissue clearance by the mononuclear phagocytic system. The major exponent of this system is the macrophage. Regardless the nanomaterial composition, macrophages can detect and incorporate foreign bodies by phagocytosis. Therefore, the simplest explanation is that any injected nanoparticle will be probably taken up by macrophages. This explains, in part, the natural accumulation of most nanoparticles in the spleen, lymph nodes, and liver (the main organs of the mononuclear phagocytic system). For this reason, recent investigations are devoted to design nanoparticles for specific macrophage targeting in diseased tissues. The aim of this review is to describe current strategies for the design of nanoparticles to target macrophages and to modulate their immunological function involved in different diseases with special emphasis on chronic inflammation, tissue regeneration, and cancer. |
| Databáze: | OpenAIRE |
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