Efficient pH Dependent Drug Delivery to Target Cancer Cells by Gold Nanoparticles Capped with Carboxymethyl Chitosan
| Autor: | A. Madhusudhan, Sumathi Natarajan, Anren Hu, Surya S. Singh, Guttena Veerabhadram, Ming-Yeh Yang, Dudde Anil Kumar, Gangapuram Bhagavanth Reddy, M. Venkatesham |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Nigericin
Ionophore macromolecular substances doxorubicin Catalysis Article Inorganic Chemistry Chitosan lcsh:Chemistry chemistry.chemical_compound Drug Delivery Systems Cell Line Tumor Neoplasms carboxymethyl chitosan gold nanoparticles pH-sensitive drug delivery cellular uptake cytotoxicity medicine polycyclic compounds Humans Doxorubicin Physical and Theoretical Chemistry Particle Size Cytotoxicity Molecular Biology lcsh:QH301-705.5 Spectroscopy Antibiotics Antineoplastic Organic Chemistry technology industry and agriculture General Medicine Computer Science Applications carbohydrates (lipids) chemistry Biochemistry lcsh:Biology (General) lcsh:QD1-999 Colloidal gold Delayed-Action Preparations Cancer cell Drug delivery Nanoparticles Gold medicine.drug Nuclear chemistry |
| Zdroj: | International Journal of Molecular Sciences; Volume 15; Issue 5; Pages: 8216-8234 International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 15, Iss 5, Pp 8216-8234 (2014) |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms15058216 |
| Popis: | Doxorubicin (DOX) was immobilized on gold nanoparticles (AuNPs) capped with carboxymethyl chitosan (CMC) for effective delivery to cancer cells. The carboxylic group of carboxymethyl chitosan interacts with the amino group of the doxorubicin (DOX) forming stable, non-covalent interactions on the surface of AuNPs. The carboxylic group ionizes at acidic pH, thereby releasing the drug effectively at acidic pH suitable to target cancer cells. The DOX loaded gold nanoparticles were effectively absorbed by cervical cancer cells compared to free DOX and their uptake was further increased at acidic conditions induced by nigericin, an ionophore that causes intracellular acidification. These results suggest that DOX loaded AuNPs with pH-triggered drug releasing properties is a novel nanotheraputic approach to overcome drug resistance in cancer. |
| Databáze: | OpenAIRE |
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