Neuropsychological Performance Is Positively Associated with Plasma Albumin in Healthy Adults
| Autor: | Virginie Lam, Jonathan K. Foster, Ryusuke Takechi, John C.L. Mamo, Matthew A. Albrecht, Sayeh Heidari-Nejad |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty In Vitro Techniques Neuropsychological Tests Liver disease Cognition Internal medicine medicine Humans Effects of sleep deprivation on cognitive performance Serum Albumin Biological Psychiatry Aged medicine.diagnostic_test Neuropsychology Albumin Neuropsychological test Middle Aged medicine.disease Psychiatry and Mental health Neuropsychology and Physiological Psychology Endocrinology Health Female Psychology Psychomotor Performance Homeostasis Stroop effect Kidney disease |
| Zdroj: | Neuropsychobiology. 69:31-38 |
| ISSN: | 1423-0224 0302-282X |
| Popis: | Background: Albumin serves a range of physiological functions that are vital to overall brain and cognitive health. Indeed, associations between cognitive performance and albumin have been demonstrated in individuals with chronic liver or kidney disease and in patients with a high urinary excretion of albumin. However, an association of plasma albumin with cognitive performance has not been reported in otherwise healthy participants with clinically acceptable plasma albumin concentrations. Method: This study utilized a wide-ranging neuropsychological test battery to investigate the relationship between cognitive performance and plasma albumin homeostasis in 222 healthy participants (143 females) between the ages of 43 and 84 years (mean 65 years). Results: Albumin both with and without the covariates of age, sex and acute-phase proteins was positively associated with enhanced performance on a range of neuropsychological domains including perceptual speed, Stroop and verbal ability. Albumin manifested generally positive but less robust associations with secondary and primary memory. Conclusion: The results indicate that there is a positive association between albumin and cognitive performance in physiologically healthy participants free of chronic renal or liver disease. |
| Databáze: | OpenAIRE |
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