The Patient's Anastrozole Compliance to Therapy (PACT) Program: a randomized, in-practice study on the impact of a standardized information program on persistence and compliance to adjuvant endocrine therapy in postmenopausal women with early breast cancer
| Autor: | R. Kreienberg, P. Hadji, C Windemuth-Kieselbach, S Zaun, Nadia Harbeck, Maria Blettner, C. Jackisch, H.-J. Lück |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Antineoplastic Agents Hormonal medicine.drug_class medicine.medical_treatment Anastrozole Breast Neoplasms Pact Persistence (computer science) Medication Adherence Eosinophilia–myalgia syndrome Breast cancer Internal medicine Nitriles medicine Humans Prospective Studies Early Detection of Cancer Aged Gynecology Aromatase inhibitor business.industry Surrogate endpoint Hematology Middle Aged Triazoles medicine.disease Postmenopause Oncology Patient Compliance Female business Adjuvant medicine.drug Follow-Up Studies |
| Zdroj: | Annals of oncology : official journal of the European Society for Medical Oncology. 24(6) |
| ISSN: | 1569-8041 |
| Popis: | BACKGROUND Compliance and persistence are often overlooked in adjuvant breast cancer treatment. PATIENTS AND METHODS PACT was a prospective, multicenter, randomized, open, parallel-group study assessing whether educational materials (EMs) enhanced compliance with aromatase inhibitor (AI) therapy in postmenopausal women with early, hormone-receptor-positive (HR+) breast cancer. The primary end points were compliance (proportion taking ≥ 80% anastrozole) at 12 months and persistence (proportion reporting anastrozole intake during the study period). RESULTS Four thousand eight hundred and forty-four patients were randomly assigned 1:1 to receive standard therapy or standard therapy with EMs. There was no difference between arms in compliance (N = 2740; 88.5%/88.8%, respectively, P = 0.81) or persistence rates (N = 2740; 40.5%/43.0%, respectively, P = 0.18). Modified end point analyses found no differences in compliance between arms based on the classification of: (i) patients with missing documentation or follow-up visit |
| Databáze: | OpenAIRE |
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