Cytotoxic triterpenes from Crataegus pinnatifida
| Autor: | Hyun Ju Jung, Jong Pill Lee, Young Ho Kim, Sang Myung Lee, Chong Ock Lee, Byung Sun Min, KiHwan Bae, Jun Sung Lee, MinKyun Na |
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| Rok vydání: | 2000 |
| Předmět: |
Magnetic Resonance Spectroscopy
Spectrophotometry Infrared Rosaceae Terpene chemistry.chemical_compound Mice Ursolic acid Drug Discovery Tumor Cells Cultured Cytotoxic T cell Animals Humans Rosales Cytotoxicity Korea biology Organic Chemistry Crataegus pinnatifida biology.organism_classification Antineoplastic Agents Phytogenic In vitro Triterpenes Plant Leaves chemistry Biochemistry Cell culture Molecular Medicine Spectrophotometry Ultraviolet Drug Screening Assays Antitumor |
| Zdroj: | Archives of pharmacal research. 23(2) |
| ISSN: | 0253-6269 |
| Popis: | Bioassay-guided fractionation of Crataegus pinnatifida (Rosaceae) gave two cytotoxic ursane-type triterpenes which were identified as uvaol (1) and ursolic acid (2) by physicochemical and spectroscopic methods. 3-Oxo-ursolic acid (3) was synthesized from ursolic acid (2) by Jones method. The cytotoxic activities of these compounds were tested against murine L1210 and human cancer cell lines (A549, SK-OV-3, SK-MEL-2, XF498, and HCT15) in vitro. Compounds 1 and 2 showed moderate cytotoxicities against L1210, whereas they showed weak activities against human cancer cell lines. However, compound 3 exhibited potent cytotoxic activities both in murine and in human cancer cell lines. |
| Databáze: | OpenAIRE |
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