Effect of the 21-aminosteroid, U-74389F, on hyperoxic lung injury in rats
| Autor: | E. J. Jacobsen, Robert L. Griffin, Ivan M. Richards, S. F. Fidler |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
Thorax medicine.medical_specialty Pathology Neutrophils medicine.medical_treatment Immunology Lung injury Toxicology Antioxidants Rats Sprague-Dawley Internal medicine medicine Animals Pharmacology (medical) Lung Pregnatrienes Pharmacology Hyperoxia Chemotherapy medicine.diagnostic_test business.industry Respiratory disease respiratory system medicine.disease Rats respiratory tract diseases Oxygen Pleural Effusion Endocrinology Bronchoalveolar lavage medicine.anatomical_structure medicine.symptom business Aminosteroid medicine.drug |
| Zdroj: | Agents and Actions. 39:136-138 |
| ISSN: | 1420-908X 0065-4299 |
| Popis: | Hyperoxia (95% oxygen) in rats caused an increase in lung weight and an accumulation of fluid in the thorax. The mean lung wet weight of air-breathing controls at 60 h was 1.2 +/- 0.01 g, and that of vehicle-treated, oxygen-exposed animals was 2.45 +/- 0.05 g. Treatment with the 21-aminosteroid U-74389F, 3, 10, and 30 mg/kg twice daily throughout oxygen exposure, produced 8, 42, and 18% inhibition of the oxygen-induced increase in lung weight, respectively. However, U-74389F did not inhibit the hyperoxia-induced accumulation of neutrophils in bronchoalveolar lavage fluid. No pleural fluid could be aspirated from the thorax of air-breathing controls. The volume of pleural fluid in oxygen-exposed, vehicle-treated animals and animals treated with 3, 10, and 30 mg/kg U-74389F b.i.d. was 6.5 +/- 0.9, 2.6 +/- 0.6, 0.8 +/- 0.3, and 1.3 +/- 0.5 ml, respectively. U-74389F or its biologs are of potential value for the treatment of lung diseases in which oxidant damage has been implicated. |
| Databáze: | OpenAIRE |
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