Perioperative neutron brachytherapy with Californium-252
| Autor: | Vladimir A. Anikin, Vladimir N. Ivanov, L. F. Ivanova, Victor S. Medvedev, Boris M. Vtyurin |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Cancer Research Radiography medicine.medical_treatment Brachytherapy chemistry.chemical_element Russia Humans Medicine Radiology Nuclear Medicine and imaging Radiation treatment planning Retrospective Studies Neutrons Radiation business.industry Californium Perioperative Middle Aged Combined Modality Therapy Neutron therapy Parotid gland Radiation therapy medicine.anatomical_structure Oncology chemistry Head and Neck Neoplasms Neoplasm Recurrence Local business Nuclear medicine |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 23:873-879 |
| ISSN: | 0360-3016 |
| Popis: | Between 1973 and 1988, 495 patients were treated with Cf-252 neutron brachytherapy. Cf-252 neutron therapy sources developed in the USSR has been used in the trial. A numerical reconstruction method for localization of Cf-252 cell coordinates by projections on orthogonal radiographs has been designed and used for treatment planning. Eight (1.6%) patients with recurrent and persistent head and neck tumors and ages from 32 to 48 years (mean age 43 years) were treated with Cf-252 perioperative neutron brachytherapy. There were three patients with oral cavity, one with oropharynx, three with parotid gland cancers, and one with a skin tumor. The dose rate ranged from 3.2 cGy/h to 11.1 cG/h, the minimal peripheral dose ranged from 3 Gy to 8 Gy. Initial local control was achieved in all patients. Local recurrence developed in two cases. Three patients died in first year after therapy. Three patients died during the second year. Two patients are long term cures, one patient more than nine years and one eight years, that is 25% of the treated patients. |
| Databáze: | OpenAIRE |
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